| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4020645 | B | Inhibition of interaction of CD40 in human THP-1 cells with recombinant human CD40L assessed as reduction in CD40L-induced MCH-2 upregulation after 48 hrs by DAPI-staining based flow cytometric analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 2. | ALA4020646 | B | Inhibition of human Fc-conjugated CD40/FLAG-tagged biotinylated CD40L costimulatory protein-protein interaction incubated for 1 hr by ELISA-type assay | Homo sapiens | 10 | protein format | Scientific Literature | ||
| 3. | ALA4020647 | B | Inhibition of human Fc-conjugated TNF-R/FLAG-tagged biotinylated TNFalpha protein-protein interaction incubated for 1 hr by ELISA-type assay | Homo sapiens | 7 | assay format | Scientific Literature | ||
| 4. | ALA4020648 | B | Selectivity ratio of IC50 for human Fc-conjugated TNF-R/FLAG-tagged biotinylated TNFalpha protein-protein interaction to IC50 for human Fc-conjugated CD40/FLAG-tagged biotinylated CD40L costimulatory protein-protein interaction | Homo sapiens | 7 | assay format | Scientific Literature | ||
| 5. | ALA4020649 | B | Inhibition of interaction of CD40 (unknown origin) transfected in HEK Blue cells with recombinant human CD40L assessed as reduction in CD40L-induced NF-kappaB activation after 18 hrs by spectrophotometry based SEAP reporter gene assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 6. | ALA4020651 | A | Cytotoxicity against human THP1 cells assessed as reduction in cell viability at 100 uM after 48 hrs by MTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 7. | ALA4020652 | T | Mutagenicity in Salmonella typhimurium TA100 up to 500 uM measured daily up to day 6 by Ames test | Salmonella enterica subsp. enterica serovar Typhimurium | 2 | assay format | Scientific Literature | ||
| 8. | ALA4020653 | B | Inhibition of interaction of CD40 in human B cells with recombinant human CD40L assessed as reduction in CD40L-induced cell proliferation after 48 hrs by BrdU incorporation-based ELISA | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 9. | ALA4020654 | B | Inhibition of interaction of CD40 in promoter/enhancer region of aicda-fused Ds-Red reporter transfected human B cells with recombinant human CD40L assessed as reduction in CD40L/IL-4-induced B cell activation by measuring AID expression after 2 days by flow cytometric analysis | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 10. | ALA4020658 | B | Inhibition of human Fc-conjugated Mac1/FLAG-tagged biotinylated CD40L protein-protein interaction incubated for 1 hr by ELISA-type assay | Homo sapiens | 6 | protein format | Scientific Literature | ||
| 11. | ALA4020659 | B | Ratio of IC50 for human Fc-conjugated CD40/FLAG-tagged biotinylated CD40L costimulatory protein-protein interaction in presence of Triton-X 100 to IC50 for human Fc-conjugated CD40/FLAG-tagged biotinylated CD40L costimulatory protein-protein interaction in absence of Triton-X 100 | Homo sapiens | 4 | protein format | Scientific Literature | ||
| 12. | ALA4020661 | P | Solubility of the compound in water | 3 | small-molecule physicochemical format | Scientific Literature |
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