# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4031112 | Binding | Inhibition of Atrovastatin-PEG3-FITC binding to PDEdelta (unknown origin) incubated for 60 mins by fluorescence anisotropy assay | Homo sapiens | 17 | ALA4028858 | single protein format | Scientific Literature | |
2. | ALA4031113 | Physicochemical | Aqueous solubility of the compound at 5 mg/ml measured after 24 hrs by HPLC method | 13 | ALA4028858 | small-molecule physicochemical format | Scientific Literature | ||
3. | ALA4031114 | Functional | Antiproliferative activity against KRAS-dependent human Capan1 cells after 48 hrs by CCK8 assay | Homo sapiens | 3 | ALA4028858 | cell-based format | Scientific Literature | |
4. | ALA4031116 | Functional | Induction of apoptosis in KRAS-dependent human Capan1 cells at 25 uM incubated for 48 hrs by Annexin-V FITC/propidium iodide staining-based flow cytometry relative to control | Homo sapiens | 3 | ALA4028858 | cell-based format | Scientific Literature | |
5. | ALA4031118 | Functional | Induction of apoptosis in KRAS-dependent human Capan1 cells incubated for 48 hrs by Annexin-V FITC/propidium iodide staining-based flow cytometry | Homo sapiens | 2 | ALA4028858 | cell-based format | Scientific Literature | |
6. | ALA4031122 | Binding | Inhibition of PDEdelta in KRAS-dependent human Capan1 cells assessed as downregulation of EGF-induced AKT phosphorylation at Ser473 at 10 uM incubated for >5 hrs by Western blot method | Homo sapiens | 1 | ALA4028858 | assay format | Scientific Literature | |
7. | ALA4031123 | Binding | Inhibition of PDEdelta in KRAS-dependent human Capan1 cells assessed as downregulation of EGF-induced ERK phosphorylation at Thr202/Thr204 at 10 uM incubated for >5 hrs by Western blot method | Homo sapiens | 1 | ALA4028858 | assay format | Scientific Literature | |
8. | ALA4031126 | Binding | Inhibition of PDEdelta in KRAS-dependent human Capan1 cells assessed as increase in endogenous RAS distribution to endomembranes at 10 uM incubated for 2 hrs by immunofluorescence staining based method | Homo sapiens | 1 | ALA4028858 | assay format | Scientific Literature | |
9. | ALA4031128 | Functional | Downregulation of PDEdelta protein expression in KRAS-dependent human Capan1 cells at 10 uM incubated for 2 hrs by immunofluorescence staining-based method | Homo sapiens | 1 | ALA4028858 | cell-based format | Scientific Literature | |
10. | ALA4031132 | Functional | Potency index, ratio of deltazinone IC50 to test compound IC50 for KRAS-dependent human Capan1 cells | Homo sapiens | 1 | ALA4028858 | cell-based format | Scientific Literature |