# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4019724 | B | Silent agonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as induction of PNU-120596-stimulated peak current response at 30 uM administered for 12 secs followed by washout period for 181 secs by voltage clamp technique relative to acetylcholine | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
2. | ALA4019725 | B | Silent agonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as induction of PNU-120596-stimulated peak current response at 10 uM administered for 12 secs followed by washout period for 181 secs by voltage clamp technique relative to acetylcholine | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
3. | ALA4019726 | B | Silent agonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as induction of PNU-120596-stimulated peak current response at 100 uM administered for 12 secs followed by washout period for 181 secs by voltage clamp technique relative to acetylcholine | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
4. | ALA4019728 | B | Antagonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response administered for 12 secs followed by washout period for 181 secs by voltage clamp technique | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
5. | ALA4019730 | P | Hydrolytic stability of compound in water at 8.4 mM up to 60 days by [1H]-NMR spectroscopy | 1 | small-molecule physicochemical format | Scientific Literature | |||
6. | ALA4019731 | P | Hydrolytic stability of compound in Ringers-D2O buffer at 8.4 mM at pH 7.2 up to 60 days by [1H]-NMR spectroscopy | 1 | small-molecule physicochemical format | Scientific Literature | |||
7. | ALA4019732 | B | Partial agonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as induction of maximum current response administered for 12 secs followed by washout period for 181 secs by voltage clamp technique | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
8. | ALA4019733 | B | Partial agonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as induction of maximum current response at 100 uM administered for 12 secs followed by washout period for 181 secs by voltage clamp technique relative to acetylcholine | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
9. | ALA4019734 | B | Induction of human alpha7 nAChR desensitization expressed in Xenopus laevis oocytes at 100 uM pretreated for 30 secs followed by PNU-120596 administered for 10 secs by voltage clamp technique relative to acetylcholine | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
10. | ALA4019735 | B | Antagonist activity at human alpha4beta2 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response administered for 6 secs followed by washout period for 241 secs by voltage clamp technique | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
11. | ALA4019736 | B | Antagonist activity at human muscle alpha3beta2 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response at 30 uM administered for 6 secs followed by washout period for 241 secs by in presence of acetylcholine voltage clamp technique | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
12. | ALA4019737 | B | Antagonist activity at human ganglionic alpha3beta2 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response at 100 uM administered for 6 secs followed by washout period for 241 secs by in presence of acetylcholine voltage clamp technique | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
13. | ALA4019738 | B | Agonist activity at human alpha4beta2 nAChR expressed in Xenopus laevis oocytes assessed as induction of current response administered for 6 secs followed by washout period for 241 secs by voltage clamp technique | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
14. | ALA4019739 | B | Agonist activity at human muscle alpha3beta2 nAChR expressed in Xenopus laevis oocytes assessed as induction of current response at 30 uM administered for 6 secs followed by washout period for 241 secs by in presence of acetylcholine voltage clamp technique | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
15. | ALA4019740 | B | Agonist activity at human ganglionic alpha3beta2 nAChR expressed in Xenopus laevis oocytes assessed as induction of current response at 30 uM administered for 6 secs followed by washout period for 241 secs by in presence of acetylcholine voltage clamp technique | Homo sapiens | 1 | cell-based format | Scientific Literature |