# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4022840 | B | Inhibition of rice alpha-glucosidase assessed as residual activity at 1 mM using 4-Np-alpha-Glc as substrate by UV-visible spectrophotometric method | Oryza sativa | 2 | ALA4020817 | assay format | Scientific Literature | |
2. | ALA4022841 | B | Inhibition of wild type C57BL/6 mouse small intestinal sucrase/isomaltase assessed as residual activity at 1 mM using sucrose as substrate after 30 mins | Mus musculus | 2 | ALA4020817 | single protein format | Scientific Literature | |
3. | ALA4022842 | B | Inhibition of recombinant human GAA assessed as residual activity at 1 mM using 4-Np-alpha-Glc as substrate by UV-visible spectrophotometric method | Homo sapiens | 2 | ALA4020817 | single protein format | Scientific Literature | |
4. | ALA4022843 | B | Inhibition of wild type C57BL/6 mouse small intestinal lactase assessed as residual activity at 1 mM using lactose as substrate after 30 mins | Mus musculus | 2 | ALA4020817 | single protein format | Scientific Literature | |
5. | ALA4022844 | B | Inhibition of Pyrococcus furiosus beta-glucosidase assessed as residual activity at 1 mM using 4 Np-beta-Glc as substrate by UV-visible spectrophotometric method | Pyrococcus furiosus | 2 | ALA4020817 | assay format | Scientific Literature | |
6. | ALA4022845 | B | Inhibition of Sulfolobus solfataricus P2 beta-glucosidase assessed as residual activity at 1 mM using 4 Np-beta-Glc as substrate by UV-visible spectrophotometric method | Saccharolobus solfataricus | 2 | ALA4020817 | assay format | Scientific Literature | |
7. | ALA4022846 | B | Inhibition of GBA1/GBA2 derived from human HL60 cells assessed as residual activity at 1 mM using 4-MU-Glc as substrate after 30 mins by fluorescence assay | Homo sapiens | 2 | ALA4020817 | assay format | Scientific Literature | |
8. | ALA4022847 | B | Inhibition of recombinant human GBA1 assessed as residual activity at 1 mM | Homo sapiens | 2 | ALA4020817 | single protein format | Scientific Literature | |
9. | ALA4022848 | B | Inhibition of beta-hexosaminidase derived from human HL60 cells assessed as residual activity at 1 mM using 4-MU-GlcNAc as substrate after 30 mins by fluorescence assay | Homo sapiens | 2 | ALA4020817 | assay format | Scientific Literature | |
10. | ALA4022849 | B | Inhibition of Thermotoga maritima alpha-galactosidase assessed as residual activity at 1 mM using 4 Np-alpha-Gal as substrate by UV-visible spectrophotometric method | Thermotoga maritima | 2 | ALA4020817 | assay format | Scientific Literature | |
11. | ALA4022850 | B | Inhibition of recombinant human alpha-gal A assessed as residual activity at 1 mM using 4 Np-alpha-Gal as substrate by UV-visible spectrophotometric method | Homo sapiens | 2 | ALA4020817 | single protein format | Scientific Literature | |
12. | ALA4022851 | B | Inhibition of Alicyclobacillus acidocaldarius beta-galactosidase assessed as residual activity at 1 mM using 2 Np-beta-Gal as substrate by UV-visible spectrophotometric method | Alicyclobacillus acidocaldarius | 2 | ALA4020817 | assay format | Scientific Literature | |
13. | ALA4022852 | B | Inhibition of beta-galactosidase derived from human HL60 cells assessed as residual activity at 1 mM using 4-MU-Gal as substrate after 30 mins by fluorescence assay | Homo sapiens | 2 | ALA4020817 | assay format | Scientific Literature | |
14. | ALA4022853 | B | Inhibition of Sulfolobus solfataricus alpha fucosidase assessed as residual activity at 1 mM using 4 Np-alpha-Fuc as substrate by UV-visible spectrophotometric method | Saccharolobus solfataricus | 2 | ALA4020817 | assay format | Scientific Literature | |
15. | ALA4022854 | B | Inhibition of wild type C57BL/6 mouse small intestinal sucrase/isomaltase using sucrose as substrate after 30 mins | Mus musculus | 2 | ALA4020817 | single protein format | Scientific Literature | |
16. | ALA4022855 | B | Inhibition of wild type C57BL/6 mouse small intestinal lactase using lactose as substrate after 30 mins | Mus musculus | 1 | ALA4020817 | single protein format | Scientific Literature | |
17. | ALA4022860 | B | Stabilization of recombinant human GAA assessed as increase in melting temperature at 0.1 to 1 mM by SYPRO orange dye-based DSF method | Homo sapiens | 1 | ALA4020817 | single protein format | Scientific Literature | |
18. | ALA4022861 | B | Allosteric enhancement of GAA p.L552P/p.L552P mutant activity in pompe disease patient derived fibroblasts at 20 uM using 4-methylunbelliferyl alpha-D-glucopyranoside as substrate preincubated for 4 days followed by substrate addition measured after 60 mins by fluorometric method relative to control | Homo sapiens | 2 | ALA4020817 | assay format | Scientific Literature | |
19. | ALA4022862 | B | Allosteric enhancement of GAA p.L552P/p.L552P mutant activity in pompe disease patient derived fibroblasts at 20 uM using 4-methylunbelliferyl alpha-D-glucopyranoside as substrate preincubated for 4 days followed by substrate addition measured after 60 mins in presence of recombinant human GAA by fluorometric method relative to control | Homo sapiens | 2 | ALA4020817 | assay format | Scientific Literature | |
20. | ALA4022863 | B | Allosteric enhancement of GAA aberrant splicing/unknown mutant activity in pompe disease patient derived fibroblasts at 20 uM using 4-methylunbelliferyl alpha-D-glucopyranoside as substrate preincubated for 4 days followed by substrate addition measured after 60 mins in presence of recombinant human GAA by fluorometric method | Homo sapiens | 2 | ALA4020817 | assay format | Scientific Literature |