| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4362366 | Physicochemical | Thermodynamic solubility of compound in water after 24 hrs by LC-UV based shake flask method | 2 | ALA4359872 | small-molecule physicochemical format | Scientific Literature | ||
| 2. | ALA4362367 | ADME | Metabolic stability in human liver microsomes assessed as parent compound remaining at 50 uM in absence of NADPH for 60 mins by LC-ESI/MS analysis | Homo sapiens | 2 | ALA4359872 | microsome format | Scientific Literature | |
| 3. | ALA4362368 | ADME | Metabolic stability in Wistar Han rat liver microsomes assessed as parent compound remaining at 50 uM in absence of NADPH for 60 mins by LC-ESI/MS analysis | Rattus norvegicus | 2 | ALA4359872 | microsome format | Scientific Literature | |
| 4. | ALA4362372 | Toxicity | Genotoxicity in human primary lymphocytes in presence of S9 fraction by GreenScreen assay | Homo sapiens | 1 | ALA4359872 | cell-based format | Scientific Literature | |
| 5. | ALA4362383 | ADME | Glutathione reactivity in Wistar Han rat liver microsomes assessed as GSH-compound adduct formation measured after 60 mins in absence of NADPH by LC-ESI/MS analysis | Rattus norvegicus | 1 | ALA4359872 | microsome format | Scientific Literature | |
| 6. | ALA4362386 | Toxicity | Genotoxicity in human primary lymphocytes assessed as induction of DNA damage up to 1000 uM by GreenScreen assay | Homo sapiens | 1 | ALA4359872 | cell-based format | Scientific Literature | |
| 7. | ALA4362388 | Toxicity | Genotoxicity in human TK6 cells in presence of S9 fraction by GreenScreen assay | Homo sapiens | 1 | ALA4359872 | cell-based format | Scientific Literature | |
| 8. | ALA4362391 | Toxicity | Genotoxicity in human TK6 cells assessed as induction of DNA damage up to 1000 uM by GreenScreen assay | Homo sapiens | 1 | ALA4359872 | cell-based format | Scientific Literature | |
| 9. | ALA4362392 | ADME | Drug metabolism in human liver microsomes assessed as aliphatic hydroxylation of paraffin linker at 50 uM measured after 60 mins in absence of NADPH by LC-ESI/MS analysis | Homo sapiens | 1 | ALA4359872 | microsome format | Scientific Literature | |
| 10. | ALA4362393 | ADME | Drug metabolism in human liver microsomes assessed as pyridine N-oxidation at 50 uM measured after 60 mins in absence of NADPH by LC-ESI/MS analysis | Homo sapiens | 1 | ALA4359872 | microsome format | Scientific Literature | |
| 11. | ALA4362394 | ADME | Drug metabolism in human liver microsomes assessed as oxidative N-dealkylation at 50 uM measured after 60 mins in absence of NADPH by LC-ESI/MS analysis | Homo sapiens | 1 | ALA4359872 | microsome format | Scientific Literature | |
| 12. | ALA4362395 | ADME | Drug metabolism in Wistar Han rat liver microsomes assessed as aliphatic hydroxylation of paraffin linker at 50 uM measured after 60 mins in absence of NADPH by LC-ESI/MS analysis | Rattus norvegicus | 1 | ALA4359872 | microsome format | Scientific Literature | |
| 13. | ALA4362396 | ADME | Drug metabolism in Wistar Han rat liver microsomes assessed as pyridine N-oxidation at 50 uM measured after 60 mins in absence of NADPH by LC-ESI/MS analysis | Rattus norvegicus | 1 | ALA4359872 | microsome format | Scientific Literature | |
| 14. | ALA4362397 | ADME | Drug metabolism in Wistar Han rat liver microsomes assessed as oxidative N-dealkylation at 50 uM measured after 60 mins in absence of NADPH by LC-ESI/MS analysis | Rattus norvegicus | 1 | ALA4359872 | microsome format | Scientific Literature | |
| 15. | ALA4362398 | Physicochemical | Kinetic aqueous solubility of the compound in 80:20 PBS/acetonitrile solution at 200 uM by HTS assay | 2 | ALA4359872 | small-molecule physicochemical format | Scientific Literature | ||
| 16. | ALA4008461 | Binding | Inhibition of recombinant mouse NAMPT expressed in bacterial expression system using nicotinamide as substrate after 1 hr by fluorescence based NMNAT-3 enzyme coupled assay | Mus musculus | 39 | ALA4007408 | assay format | Scientific Literature | |
| 17. | ALA4008462 | Functional | Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability after 56 hrs by MTT assay | Homo sapiens | 39 | ALA4007408 | cell-based format | Scientific Literature | |
| 18. | ALA4008463 | Binding | Inhibition of NAMPT in human Jurkat T cells assessed as reduction in NAD levels | Homo sapiens | 3 | ALA4007408 | cell-based format | Scientific Literature | |
| 19. | ALA4008470 | ADME | Drug metabolism in human liver microsomes assessed as aliphatic hydroxylation of paraffin linkers by LC-ESI-MS or LC-UV analysis | Homo sapiens | 1 | ALA4007408 | assay format | Scientific Literature | |
| 20. | ALA4008471 | ADME | Stability in human liver microsomes after 60 mins by LC-ESI-MS analysis | Homo sapiens | 4 | ALA4007408 | assay format | Scientific Literature |
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