| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4042549 | B | Binding affinity to human GABAA alpha3beta3gamma2 receptor expressed in HEK293 cells assessed as GABA-induced membrane potential change preincubated for 3 mins followed by addition of GABA measured after 3 mins by FLIPR assay | Homo sapiens | 10 | ALA4041524 | cell-based format | Scientific Literature | |
| 2. | ALA4042550 | A | Metabolic stability in human liver microsomes assessed as compound remaining at 4 uM measured after 30 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 10 | ALA4041524 | assay format | Scientific Literature | |
| 3. | ALA4042551 | A | Metabolic stability in mouse liver microsomes assessed as compound remaining at 4 uM measured after 30 mins in presence of NADPH by LC-MS/MS analysis | Mus musculus | 10 | ALA4041524 | assay format | Scientific Literature | |
| 4. | ALA4042552 | A | Metabolic stability in rat liver microsomes assessed as compound remaining at 4 uM measured after 30 mins in presence of NADPH by LC-MS/MS analysis | Rattus norvegicus | 10 | ALA4041524 | assay format | Scientific Literature | |
| 5. | ALA4042553 | A | Cytotoxicity against HEK293T cells assessed as viable cells measured after 18 hrs by CellTiter-Glo assay | Homo sapiens | 10 | ALA4041524 | cell-based format | Scientific Literature | |
| 6. | ALA4042554 | A | Binding affinity to human GABAA alpha1beta3gamma2 receptor expressed in HEK293 cells assessed as GABA-induced membrane potential change preincubated for 3 mins followed by addition of GABA measured after 3 mins by FLIPR assay | Homo sapiens | 10 | ALA4041524 | cell-based format | Scientific Literature | |
| 7. | ALA4042555 | A | Total plasma concentration in Sprague-Dawley rat at 10 mg/kg, po measured after 15 mins by LC-MS/MS analysis | Rattus norvegicus | 5 | ALA4041524 | organism-based format | Scientific Literature | |
| 8. | ALA4042556 | A | Total plasma concentration in Sprague-Dawley rat at 10 mg/kg, po measured after 30 mins by LC-MS/MS analysis | Rattus norvegicus | 5 | ALA4041524 | organism-based format | Scientific Literature | |
| 9. | ALA4042557 | A | Total plasma concentration in Sprague-Dawley rat at 10 mg/kg, po measured after 60 mins by LC-MS/MS analysis | Rattus norvegicus | 5 | ALA4041524 | organism-based format | Scientific Literature | |
| 10. | ALA4042558 | A | Total plasma concentration in Sprague-Dawley rat at 10 mg/kg, po measured after 120 mins by LC-MS/MS analysis | Rattus norvegicus | 5 | ALA4041524 | organism-based format | Scientific Literature | |
| 11. | ALA4042560 | A | Drug uptake in Sprague-Dawley rat brain at 10 mg/kg, po measured after 60 mins by LC-MS/MS analysis | Rattus norvegicus | 2 | ALA4041524 | organism-based format | Scientific Literature | |
| 12. | ALA4042561 | A | Drug metabolism in Sprague-Dawley rat brain assessed as (E)-8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylic acid formation at 10 mg/kg, po measured after 120 mins by LC-MS/MS analysis | Rattus norvegicus | 5 | ALA4041524 | organism-based format | Scientific Literature | |
| 13. | ALA4042564 | F | Anxiolytic-like activity in Swiss Webster mouse marble burying model of anxiety assessed as suppression of marble burying activity at 30 mg/kg, ip administered 30 mins prior to test relative to vehicle-control | Mus musculus | 6 | ALA4041524 | organism-based format | Scientific Literature | |
| 14. | ALA4042566 | T | Toxicity in Swiss mouse assessed as change in motor coordination by measuring number of falls from the rotating rod at 10 mg/kg, ip administered 30 mins prior to testing measured for 2 mins by rotarod test relative to control | Mus musculus | 6 | ALA4041524 | organism-based format | Scientific Literature | |
| 15. | ALA4042567 | T | Toxicity in Swiss mouse assessed as change in motor coordination by measuring number of falls from the rotating rod at 30 mg/kg, ip administered 30 mins prior to testing measured for 2 mins by rotarod test relative to control | Mus musculus | 10 | ALA4041524 | organism-based format | Scientific Literature | |
| 16. | ALA4042568 | B | Modulation of recombinant GABA alpha2beta3gamma2 receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as change in GABA-induced EC(3 to 6) current at 100 nM by two-electrode voltage clamp assay | Homo sapiens | 2 | ALA4041524 | cell-based format | Scientific Literature | |
| 17. | ALA4042569 | B | Modulation of recombinant GABA alpha3beta3gamma2 receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as change in GABA-induced EC(3 to 6) current at 100 nM by two-electrode voltage clamp assay | Homo sapiens | 2 | ALA4041524 | cell-based format | Scientific Literature | |
| 18. | ALA4042570 | B | Modulation of recombinant GABA alpha1beta3gamma2 receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as change in GABA-induced EC(3 to 6) current at 1 uM by two-electrode voltage clamp assay | Homo sapiens | 2 | ALA4041524 | cell-based format | Scientific Literature | |
| 19. | ALA4042571 | B | Modulation of recombinant GABA alpha2beta3gamma2 receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as change in GABA-induced EC(3 to 6) current at 1 uM by two-electrode voltage clamp assay | Homo sapiens | 2 | ALA4041524 | cell-based format | Scientific Literature | |
| 20. | ALA4042572 | B | Modulation of recombinant GABA alpha3beta3gamma2 receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as change in GABA-induced EC(3 to 6) current at 1 uM by two-electrode voltage clamp assay | Homo sapiens | 2 | ALA4041524 | cell-based format | Scientific Literature |
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