| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4020494 | F | Elevation of cGMP levels in hippocampal slices of wild type C57Bl6 mouse at 3 to 10 mg/kg, ip administered for 30 mins followed by foot shock measured at 10 to 180 secs after shock by enzyme immunoassay | Mus musculus | 1 | ALA4017542 | organism-based format | Scientific Literature | |
| 2. | ALA4020495 | B | Inhibition of human recombinant PDE5A1 using FAM-labelled cGMP as substrate after 60 mins by fluorescence polarization assay | Homo sapiens | 18 | ALA4017542 | single protein format | Scientific Literature | |
| 3. | ALA4020496 | B | Inhibition of human recombinant PDE6C using FAM-labelled cGMP as substrate after 60 mins by fluorescence polarization assay | Homo sapiens | 18 | ALA4017542 | single protein format | Scientific Literature | |
| 4. | ALA4020497 | B | Selectivity ratio of IC50 for human recombinant PDE6C to IC50 for human recombinant PDE5A1 | Homo sapiens | 2 | ALA4017542 | assay format | Scientific Literature | |
| 5. | ALA4020498 | F | Elevation of cGMP levels in hippocampal slices of wild type ip dosed C57Bl6 mouse administered for 30 mins followed by foot shock measured at 10 to 60 secs after shock by enzyme immunoassay | Mus musculus | 1 | ALA4017542 | organism-based format | Scientific Literature | |
| 6. | ALA4020499 | F | Elevation of cGMP levels in hippocampal slices of wild type C57Bl6 mouse at 3 mg/kg, ip administered for 30 mins followed by foot shock measured at 10 to 60 secs after shock by enzyme immunoassay relative to control | Mus musculus | 1 | ALA4017542 | organism-based format | Scientific Literature | |
| 7. | ALA4020500 | F | Elevation of cGMP levels in hippocampal slices of wild type C57Bl6 mouse at 10 mg/kg, ip administered for 30 mins followed by foot shock measured at 10 to 60 secs after shock by enzyme immunoassay relative to control | Mus musculus | 1 | ALA4017542 | organism-based format | Scientific Literature | |
| 8. | ALA4020501 | F | Elevation of cGMP levels in hippocampal slices of wild type C57Bl6 mouse at 10 mg/kg, ip administered for 30 mins followed by foot shock measured at 180 secs after shock by enzyme immunoassay relative to control | Mus musculus | 1 | ALA4017542 | organism-based format | Scientific Literature | |
| 9. | ALA4020502 | F | Elevation of cGMP levels in hippocampal slices of wild type C57Bl6 mouse at 3 mg/kg, ip administered for 30 mins followed by foot shock measured at 180 secs after shock by enzyme immunoassay | Mus musculus | 1 | ALA4017542 | organism-based format | Scientific Literature | |
| 10. | ALA4020503 | F | Antialzheimer activity in APP1/PS1 transgenic mouse hippocampal slices assessed as long-term residual potentiation at 50 nM administered via bath perfusion for 10 mins prior to tetanus measured at the last 5 mins of 2 hrs recording (Rvb = 137.90 +/- 10.83%) | Mus musculus | 1 | ALA4017542 | tissue-based format | Scientific Literature | |
| 11. | ALA4020504 | A | Effect on long-term residual potentiation in wild type C57Bl6 mouse hippocampal slices at 50 nM administered via bath perfusion for 10 mins prior to tetanus measured at the last 5 mins of 2 hrs recording | Mus musculus | 1 | ALA4017542 | tissue-based format | Scientific Literature | |
| 12. | ALA4020505 | F | Antialzheimer activity in 3 to 4 months old APP1/PS1 transgenic mouse model assessed as long-term residual potentiation in hippocampal slices at 3 mg/kg, ip administered daily for 3 weeks measured at age of 6 to 7 months (Rvb = 164.11 +/- 10.36%) | Mus musculus | 1 | ALA4017542 | organism-based format | Scientific Literature | |
| 13. | ALA4020506 | P | Kinetic solubility of compound in phosphate buffer after 18 hrs by turbidimetric method | 3 | ALA4017542 | small-molecule physicochemical format | Scientific Literature | ||
| 14. | ALA4020507 | A | Plasma concentration in mouse at 25 mg/kg, ip measured at 0.25 hrs post dose by LC/MS analysis | Mus musculus | 1 | ALA4017542 | organism-based format | Scientific Literature | |
| 15. | ALA4020508 | A | Drug level in mouse brain at 25 mg/kg, ip measured at 0.25 hrs post dose by LC/MS analysis | Mus musculus | 1 | ALA4017542 | organism-based format | Scientific Literature | |
| 16. | ALA4020509 | A | Plasma half life in mouse at 25 mg/kg, ip measured at 0.25 hrs post dose by LC/MS analysis | Mus musculus | 1 | ALA4017542 | organism-based format | Scientific Literature | |
| 17. | ALA4020510 | A | Ratio of drug level in mouse brain to plasma at 25 mg/kg, ip measured at 0.25 hrs post dose by LC/MS analysis | Mus musculus | 1 | ALA4017542 | organism-based format | Scientific Literature | |
| 18. | ALA4020511 | A | Half life in mouse liver microsomes at 1 uM measured up to 60 mins by LC-MS/MS analysis | Mus musculus | 1 | ALA4017542 | assay format | Scientific Literature | |
| 19. | ALA4020512 | A | Half life in human liver microsomes at 1 uM measured up to 60 mins by LC-MS/MS analysis | Homo sapiens | 1 | ALA4017542 | assay format | Scientific Literature | |
| 20. | ALA4020513 | F | Antialzheimer activity in APP1/PS1 transgenic mouse assessed as rescue contextual memory by measuring freezing at 3 mg/kg, ip administered daily for 3 weeks by contextual fear memory test (Rvb = 15%) | Mus musculus | 1 | ALA4017542 | organism-based format | Scientific Literature |
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