#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA4032658	F	In vivo agonist activity at FXR in po dosed Sprague-Dawley rat assessed as induction of FGF15 protein level in plasma administered once daily for 14 days measured 7 hrs post last dose on day 14	Rattus norvegicus	1	ALA4028903	organism-based format	Scientific Literature
2.	ALA4032659	A	AUC in mouse at 10 mg/kg, po administered via gavage by LC-MS/MS analysis	Mus musculus	1	ALA4028903	organism-based format	Scientific Literature
3.	ALA4032660	B	Agonist activity at recombinant human GST-tagged FXR ligand binding domain (193 to 472 residues) expressed in baculovirus infected insect cells assessed as induction of interaction with biotin labelled SRC-1 after 1 hr by HTRF assay	Homo sapiens	15	ALA4028903	cell-based format	Scientific Literature
4.	ALA4032661	B	Agonist activity at recombinant human GST-tagged FXR ligand binding domain (193 to 472 residues) expressed in baculovirus infected insect cells assessed as induction of interaction with biotin labelled SRC-1 after 1 hr by HTRF assay relative to GW4064	Homo sapiens	14	ALA4028903	cell-based format	Scientific Literature
5.	ALA4032662	B	Agonist activity at human FXR expressed in HEK293T cells assessed as BSEP promoter driven cellular transcriptional activity after 24 hrs by luciferase reporter gene assay	Homo sapiens	15	ALA4028903	cell-based format	Scientific Literature
6.	ALA4032663	B	Agonist activity at human FXR expressed in HEK293T cells assessed as BSEP promoter driven cellular transcriptional activity after 24 hrs by luciferase reporter gene assay relative to GW4064	Homo sapiens	14	ALA4028903	cell-based format	Scientific Literature
7.	ALA4032664	P	Solubility of the compound in fasted state simulated intestinal fluid at pH 6.8		11	ALA4028903	small-molecule physicochemical format	Scientific Literature
8.	ALA4032665	P	Dissociation constant, pKa of compound		6	ALA4028903	small-molecule physicochemical format	Scientific Literature
9.	ALA4032666	A	Extraction ratio in rat liver microsomes	Rattus norvegicus	11	ALA4028903	assay format	Scientific Literature
10.	ALA4032667	A	Extraction ratio in human liver microsomes	Homo sapiens	11	ALA4028903	assay format	Scientific Literature
11.	ALA4032668	A	Clearance in rat at 3 mg/kg, iv by LC-MS/MS analysis	Rattus norvegicus	8	ALA4028903	organism-based format	Scientific Literature
12.	ALA4032669	A	Volume of distribution at steady state in rat at 3 mg/kg, iv by LC-MS/MS analysis	Rattus norvegicus	8	ALA4028903	organism-based format	Scientific Literature
13.	ALA4032670	A	Terminal half life in rat at 3 mg/kg, iv by LC-MS/MS analysis	Rattus norvegicus	8	ALA4028903	organism-based format	Scientific Literature
14.	ALA4032671	A	AUC in rat at 10 mg/kg, po administered via gavage by LC-MS/MS analysis	Rattus norvegicus	8	ALA4028903	organism-based format	Scientific Literature
15.	ALA4032672	A	Cmax in rat at 10 mg/kg, po administered via gavage by LC-MS/MS analysis	Rattus norvegicus	8	ALA4028903	organism-based format	Scientific Literature
16.	ALA4032673	A	Oral bioavailability in rat at 10 mg/kg administered via gavage by LC-MS/MS analysis	Rattus norvegicus	8	ALA4028903	organism-based format	Scientific Literature
17.	ALA4032674	B	Agonist activity at FXR in rat primary hepatocytes assessed as induction of BSEP mRNA level after 24 hrs by qPCR analysis	Rattus norvegicus	1	ALA4028903	cell-based format	Scientific Literature
18.	ALA4032675	B	Agonist activity at FXR in rat primary hepatocytes assessed as induction of SHP mRNA level after 24 hrs by qPCR analysis	Rattus norvegicus	1	ALA4028903	cell-based format	Scientific Literature
19.	ALA4032676	B	Agonist activity at FXR in rat primary hepatocytes assessed as induction of SHP mRNA level at 10 nM after 24 hrs by qPCR analysis relative to control	Rattus norvegicus	1	ALA4028903	cell-based format	Scientific Literature
20.	ALA4032677	B	Agonist activity at FXR in rat primary hepatocytes assessed as induction of SHP mRNA level at 1 nM after 24 hrs by qPCR analysis relative to control	Rattus norvegicus	1	ALA4028903	cell-based format	Scientific Literature