| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4032660 | B | Agonist activity at recombinant human GST-tagged FXR ligand binding domain (193 to 472 residues) expressed in baculovirus infected insect cells assessed as induction of interaction with biotin labelled SRC-1 after 1 hr by HTRF assay | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 2. | ALA4032661 | B | Agonist activity at recombinant human GST-tagged FXR ligand binding domain (193 to 472 residues) expressed in baculovirus infected insect cells assessed as induction of interaction with biotin labelled SRC-1 after 1 hr by HTRF assay relative to GW4064 | Homo sapiens | 14 | cell-based format | Scientific Literature | ||
| 3. | ALA4032662 | B | Agonist activity at human FXR expressed in HEK293T cells assessed as BSEP promoter driven cellular transcriptional activity after 24 hrs by luciferase reporter gene assay | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 4. | ALA4032663 | B | Agonist activity at human FXR expressed in HEK293T cells assessed as BSEP promoter driven cellular transcriptional activity after 24 hrs by luciferase reporter gene assay relative to GW4064 | Homo sapiens | 14 | cell-based format | Scientific Literature | ||
| 5. | ALA4032664 | P | Solubility of the compound in fasted state simulated intestinal fluid at pH 6.8 | 11 | small-molecule physicochemical format | Scientific Literature | |||
| 6. | ALA4032666 | A | Extraction ratio in rat liver microsomes | Rattus norvegicus | 11 | assay format | Scientific Literature | ||
| 7. | ALA4032667 | A | Extraction ratio in human liver microsomes | Homo sapiens | 11 | assay format | Scientific Literature | ||
| 8. | ALA4032668 | A | Clearance in rat at 3 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 8 | organism-based format | Scientific Literature | ||
| 9. | ALA4032669 | A | Volume of distribution at steady state in rat at 3 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 8 | organism-based format | Scientific Literature | ||
| 10. | ALA4032670 | A | Terminal half life in rat at 3 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 8 | organism-based format | Scientific Literature | ||
| 11. | ALA4032671 | A | AUC in rat at 10 mg/kg, po administered via gavage by LC-MS/MS analysis | Rattus norvegicus | 8 | organism-based format | Scientific Literature | ||
| 12. | ALA4032672 | A | Cmax in rat at 10 mg/kg, po administered via gavage by LC-MS/MS analysis | Rattus norvegicus | 8 | organism-based format | Scientific Literature | ||
| 13. | ALA4032673 | A | Oral bioavailability in rat at 10 mg/kg administered via gavage by LC-MS/MS analysis | Rattus norvegicus | 8 | organism-based format | Scientific Literature | ||
| 14. | ALA5247740 | B | Agonist activity at human GST-tagged FXR LBD (193 to 472 residues) by FRET assay | Homo sapiens | 4 | single protein format | Scientific Literature |
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