# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3999936 | ADME | Drug metabolism in human liver microsomes assessed as glutathione reactivity by measuring sulfhydryl adduct formation at 500 uM after 60 mins in presence of [13C2,15N-Gly]GSH and NADPH generating system by LC-MS/MS analysis | Homo sapiens | 3 | ALA3997845 | assay format | Scientific Literature | |
2. | ALA3999937 | Binding | Inhibition of recombinant human HSL expressed in baculovirus infected sf9 cells using PNPB as substrate after 5 mins by spectrophotometric method | Homo sapiens | 17 | ALA3997845 | cell-based format | Scientific Literature | |
3. | ALA3999940 | ADME | Metabolic stability in rat liver microsomes assessed as parent compound remaining at 1 uM after 30 mins in presence of NADPH generating system by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA3997845 | assay format | Scientific Literature | |
4. | ALA3999941 | ADME | Cmax in Wistar rat at 3 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA3997845 | organism-based format | Scientific Literature | |
5. | ALA3999942 | ADME | AUC (0 to 7 hrs) in Wistar rat at 3 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA3997845 | organism-based format | Scientific Literature | |
6. | ALA3999943 | Functional | Antilipolytic activity in Wistar rat assessed as reduction in plasma glycerol AUC (0 to 7 hrs) at 3 mg/kg, po relative to control | Rattus norvegicus | 1 | ALA3997845 | organism-based format | Scientific Literature | |
7. | ALA4044730 | Binding | Inhibition of recombinant human HSL expressed in baculovirus infected sf9 insect cells using PNPB as substrate after 5 mins by spectrophotometric analysis | Homo sapiens | 15 | ALA4043125 | cell-based format | Scientific Literature | |
8. | ALA4044731 | Binding | Inhibition of HSL in rat adipocytes assessed as reduction in lipolysis by measuring glycerol concentration incubated for 30 mins by spectrophotometric analysis | Rattus norvegicus | 15 | ALA4043125 | cell-based format | Scientific Literature | |
9. | ALA4044737 | Physicochemical | 1-octanol/phosphate buffered saline distribution coefficient, log D of the compound at 200 uM at pH 7.4 after 30 mins by shake flask based HPLC/LC-MS analysis | 3 | ALA4043125 | small-molecule physicochemical format | Scientific Literature | ||
10. | ALA4044738 | Physicochemical | Aqueous solubility of the compound in Japanese pharmacopoeia first fluid at pH 1.2 after 4 hrs by HPLC/UV analysis | 2 | ALA4043125 | small-molecule physicochemical format | Scientific Literature | ||
11. | ALA4044739 | Physicochemical | Aqueous solubility of the compound in Japanese pharmacopoeia second fluid at pH 6.8 after 4 hrs by HPLC/UV analysis | 2 | ALA4043125 | small-molecule physicochemical format | Scientific Literature | ||
12. | ALA4044740 | Physicochemical | Aqueous solubility of the compound in FaSSIF after 4 hrs by HPLC/UV analysis | 2 | ALA4043125 | small-molecule physicochemical format | Scientific Literature |