#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA4022773	B	Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substrate assessed as decrease in IMP levels after 1 hr by mass spectrometric method	Homo sapiens	19		assay format	Scientific Literature
2.	ALA4022774	B	Inhibition of AICARFT in human NCI-H460 cells assessed as increase in ZMP levels using low folate media after 16 hrs by LC-MS method	Homo sapiens	18		cell-based format	Scientific Literature
3.	ALA4022779	P	Equilibrium aqueous solubility of the compound at pH 7.5 after 20 hrs by HPLC method		3		small-molecule physicochemical format	Scientific Literature
4.	ALA4022780	A	Permeability across apical to basolateral side in MDCK cells at 20 uM	Canis lupus familiaris	14		cell-based format	Scientific Literature
5.	ALA4022783	A	Oral bioavailability in CD-1 mouse at 10 mg/kg by LC-MS/MS method	Mus musculus	3		organism-based format	Scientific Literature
6.	ALA4022784	A	Plasma concentration in CD-1 mouse at 10 mg/kg, po after 1 hr by LC-MS/MS method	Mus musculus	12		organism-based format	Scientific Literature
7.	ALA4022785	A	Fraction unbound in CD-1 mouse plasma	Mus musculus	12		cell-free format	Scientific Literature
8.	ALA4022786	B	Inhibition of AICARFT in human NCI-H460 cells assessed as increase in ZMP levels using regular folate media after 16 hrs by LC-MS method	Homo sapiens	1		cell-based format	Scientific Literature
9.	ALA4022787	B	Inhibition of AICARFT in human MDA-MB-231 cells assessed as increase in ZMP levels using low folate media after 16 hrs by LC-MS method	Homo sapiens	1		cell-based format	Scientific Literature
10.	ALA4022788	B	Inhibition of AICARFT in human MDA-MB-231 cells assessed as increase in ZMP levels using regular folate media after 16 hrs by LC-MS method	Homo sapiens	1		cell-based format	Scientific Literature
11.	ALA4022789	F	Cytotoxicity against human NCI-H460 cells assessed as growth inhibition using low folate media after 7 days by Alamar blue assay	Homo sapiens	1		cell-based format	Scientific Literature
12.	ALA4022790	F	Cytotoxicity against human NCI-H460 cells assessed as growth inhibition using regular folate media after 7 days by Alamar blue assay	Homo sapiens	1		cell-based format	Scientific Literature
13.	ALA4022791	F	Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition using regular folate media after 7 days by Alamar blue assay	Homo sapiens	1		cell-based format	Scientific Literature
14.	ALA4022792	A	Unbound clearance in CD-1 mouse at 1 mg/kg, iv by LC-MS/MS method	Mus musculus	1		organism-based format	Scientific Literature
15.	ALA4022793	A	Unbound volume of distribution at steady state in CD-1 mouse at 1 mg/kg, iv by LC-MS/MS method	Mus musculus	1		organism-based format	Scientific Literature
16.	ALA4022794	A	Unbound AUC in CD-1 mouse at 10 mg/kg, po by LC-MS/MS method	Mus musculus	1		organism-based format	Scientific Literature
17.	ALA4022795	A	Half life in CD-1 mouse at 10 mg/kg, po by LC-MS/MS method	Mus musculus	1		organism-based format	Scientific Literature
18.	ALA4022796	A	Unbound Cmax in CD-1 mouse at 10 mg/kg, po by LC-MS/MS method	Mus musculus	1		organism-based format	Scientific Literature
19.	ALA4022803	F	In vivo inhibition of AICARFT in tumor of low folate diet fed nude mouse xenografted with human NCI-H460 cells assessed as increase in intratumoral ZMP levels at 0.3 to 30 mg/kg after 4 hrs relative to vehicle-treated control	Mus musculus	3		organism-based format	Scientific Literature
20.	ALA4022804	F	In vivo inhibition of AICARFT in tumor of low folate diet fed nude mouse xenografted with human NCI-H460 cells assessed as increase in circulating AICAr levels at 0.3 to 30 mg/kg after 4 hrs relative to vehicle-treated control	Mus musculus	3		organism-based format	Scientific Literature