Antiinflammatory activity in C3H mouse model of thioglycollate-induced lymphocyte recruitment assessed as decrease in blood neutrophils at 30 mg/kg, po dosed 15 mins before thioglycollate stimulation by Beckman Coulter counting based cell counting method relative to untreated control
Antiinflammatory activity in C3H mouse model of thioglycollate-induced lymphocyte recruitment assessed as decrease in blood lymphocytes at 30 mg/kg, po dosed 15 mins before thioglycollate stimulation by Beckman Coulter counting based cell counting method relative to untreated control
Antiinflammatory activity in C3H mouse model of thioglycollate-induced lymphocyte recruitment assessed as decrease in blood macrophages at 30 mg/kg, po dosed 15 mins before thioglycollate stimulation by Beckman Coulter counting based cell counting method relative to untreated control
Reduction in colon weight in Balb/c mouse model of dextran sodium sulfate-induced ulcerative colitis at 10 mg/kg, po dosed twice daily at days 3,4, 5 and 6 after the induction of the ulcerative colitis and measured 7 days post ulcerative colitis induction
Reduction in colon weight in Balb/c mouse model of dextran sodium sulfate-induced ulcerative colitis at 30 mg/kg, po dosed twice daily at days 3,4, 5 and 6 after the induction of the ulcerative colitis and measured 7 days post ulcerative colitis induction
Reduction in colon weight in Balb/c mouse model of dextran sodium sulfate-induced ulcerative colitis at 100 mg/kg, po dosed twice daily at days 3,4, 5 and 6 after the induction of the ulcerative colitis and measured 7 days post ulcerative colitis induction
Reduction in splenomegaly in Balb/c mouse model of dextran sodium sulfate-induced ulcerative colitis at 30 mg/kg, po dosed twice daily at days 3,4, 5 and 6 after the induction of the ulcerative colitis and measured 7 days post ulcerative colitis induction
Reduction in splenomegaly in Balb/c mouse model of dextran sodium sulfate-induced ulcerative colitis at 100 mg/kg, po dosed twice daily at days 3,4, 5 and 6 after the induction of the ulcerative colitis and measured 7 days post ulcerative colitis induction
Reduction in clinical score in Balb/c mouse model of dextran sodium sulfate-induced ulcerative colitis at 30 mg/kg, po dosed twice daily at days 3,4, 5 and 6 after the induction of the ulcerative colitis and measured 7 days post ulcerative colitis induction (Rvb = -29%)
Reduction in clinical score in Balb/c mouse model of dextran sodium sulfate-induced ulcerative colitis at 30 mg/kg, po dosed twice daily at days 3,4, 5 and 6 after the induction of the ulcerative colitis and measured 7 days post ulcerative colitis induction (Rvb = -21%)