| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4019532 | Binding | Inhibition of recombinant human N-terminal His-tagged KHK expressed in Escherichia coli BL21(DE3) using fructose as substrate incubated for 30 mins followed by ATP addition measured for 30 mins by pyruvate kinase-lactate dehydrogenase coupled enzyme assay | Homo sapiens | 9 | ALA4017511 | assay format | Scientific Literature | |
| 2. | ALA4019533 | Binding | Inhibition of recombinant rat N-terminal His-tagged KHK expressed in Escherichia coli BL21(DE3) using fructose as substrate incubated for 30 mins followed by ATP addition measured for 30 mins by pyruvate kinase-lactate dehydrogenase coupled enzyme assay | Rattus norvegicus | 2 | ALA4017511 | assay format | Scientific Literature | |
| 3. | ALA4019534 | ADME | Apparent clearance in human liver microsomes | Homo sapiens | 5 | ALA4017511 | assay format | Scientific Literature | |
| 4. | ALA4019535 | Physicochemical | Octanol/water partition coefficient, log D of the compound at pH 7.4 by shake-flask method | 5 | ALA4017511 | small-molecule physicochemical format | Scientific Literature | ||
| 5. | ALA4019536 | ADME | Apparent permeability in RRCK cells by LC-MS/MS analysis | Canis lupus familiaris | 2 | ALA4017511 | cell-based format | Scientific Literature | |
| 6. | ALA4019537 | Physicochemical | Thermodynamic solubility of compound at pH 7.4 | 2 | ALA4017511 | small-molecule physicochemical format | Scientific Literature | ||
| 7. | ALA4019538 | ADME | Fraction unbound in human plasma at 10 uM measured at 2 to 24 hrs by equilibrium dialysis method | Homo sapiens | 2 | ALA4017511 | cell-free format | Scientific Literature | |
| 8. | ALA4019562 | ADME | Unbound Cmax in rat at 300 mg/kg, po | Rattus norvegicus | 1 | ALA4017511 | organism-based format | Scientific Literature |
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