# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3993344 | B | Agonist activity at TASK3 (unknown origin) expressed in HEK293 cells assessed as increase in K+ current at 20 uM measured at +60 mV by whole-cell patch clamp method relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
2. | ALA3993346 | B | Agonist activity at TRAAK (unknown origin) expressed in HEK293 cells assessed as increase in K+ current at 20 uM measured at +60 mV by whole-cell patch clamp method relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
3. | ALA3993352 | B | Agonist activity at human TREK1 expressed in HEK293 cells assessed as increase in K+ current at 20 uM measured at +60 mV by whole-cell patch clamp method relative to control | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
4. | ALA3993354 | F | Antinociceptive activity in CD1 mouse assessed as inhibition of acetic acid-induced writhes at 10 mg/kg, sc pretreated for 15 mins followed by acetic acid challenge measured within 20 mins relative to control | Mus musculus | 53 | organism-based format | Scientific Literature | ||
5. | ALA3993357 | F | Antinociceptive activity in CD1 mouse assessed as increase in thermal-stimulus induced paw withdrawal latency at 60 mg/kg, sc measured after 30 mins by hot plate method relative to control | Mus musculus | 56 | organism-based format | Scientific Literature | ||
6. | ALA3993358 | F | Antinociceptive activity in CD1 mouse assessed as increase in thermal-stimulus induced paw withdrawal latency at 60 mg/kg, sc measured after 45 mins by hot plate method relative to control | Mus musculus | 56 | organism-based format | Scientific Literature | ||
7. | ALA3993359 | F | Antinociceptive activity in wild-type C57Bl/6J mouse assessed as increase in thermal-stimulus induced paw withdrawal latency at 60 mg/kg, sc measured after 30 mins by hot plate method relative to control | Mus musculus | 5 | organism-based format | Scientific Literature | ||
8. | ALA3993360 | F | Antinociceptive activity in wild-type C57Bl/6J mouse assessed as increase in thermal-stimulus induced paw withdrawal latency at 60 mg/kg, sc measured after 45 mins by hot plate method relative to control | Mus musculus | 5 | organism-based format | Scientific Literature | ||
9. | ALA3993361 | F | Antinociceptive activity in TREK1 deficient C57Bl/6J mouse assessed as increase in thermal-stimulus induced paw withdrawal latency at 60 mg/kg, sc measured after 30 mins by hot plate method relative to control | Mus musculus | 5 | organism-based format | Scientific Literature | ||
10. | ALA3993362 | F | Antinociceptive activity in TREK1 deficient C57Bl/6J mouse assessed as increase in thermal-stimulus induced paw withdrawal latency at 60 mg/kg, sc measured after 45 mins by hot plate method relative to control | Mus musculus | 5 | organism-based format | Scientific Literature | ||
11. | ALA3993363 | F | In vivo activation of TREK1 in C57Bl/6J mouse assessed as increase in thermal-stimulus induced paw withdrawal latency at 60 mg/kg, sc measured after 30 mins by hot plate method relative to control | Mus musculus | 5 | organism-based format | Scientific Literature | ||
12. | ALA3993364 | F | In vivo activation of TREK1 in C57Bl/6J mouse assessed as increase in thermal-stimulus induced paw withdrawal latency at 60 mg/kg, sc measured after 45 mins by hot plate method relative to control | Mus musculus | 5 | organism-based format | Scientific Literature | ||
13. | ALA3993366 | B | Agonist activity at TREK-2 (unknown origin) expressed in HEK293 cells assessed as increase in K+ current at 20 uM measured at +60 mV by whole-cell patch clamp method relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature |