| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4028335 | B | Displacement of [125I]CXCL12 from human CXCR4 expressed in HEK293 cell membranes after 1.5 hrs by Topcount method | Homo sapiens | 25 | cell-based format | Scientific Literature | ||
| 2. | ALA4028336 | T | Acute toxicity in sc dosed C57BL/6 mouse assessed as maximum tolerated dose by measuring mortality | Mus musculus | 25 | organism-based format | Scientific Literature | ||
| 3. | ALA4028337 | F | Antagonist activity at human CCR1 expressed in CHOK1 cells assessed as inhibition of CCL3-induced cAMP accumulation at 10 uM preincubated for 30 mins followed agonist addition measured after 30 to 60 mins | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA4028338 | F | Antagonist activity at human CCR5 expressed in CHOK1 cells assessed as inhibition of CCL3-induced cAMP accumulation at 10 uM preincubated for 30 mins followed agonist addition measured after 30 to 60 mins | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA4028339 | F | Antagonist activity at human CCR6 expressed in CHOK1 cells assessed as inhibition of CCL20-induced cAMP accumulation at 10 uM preincubated for 30 mins followed agonist addition measured after 30 to 60 mins | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4028340 | F | Antagonist activity at human CCR7 expressed in CHOK1 cells assessed as inhibition of CCL19-induced cAMP accumulation at 10 uM preincubated for 30 mins followed agonist addition measured after 30 to 60 mins | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4028341 | F | Antagonist activity at human CCR10 expressed in CHOK1 cells assessed as inhibition of CCL27-induced cAMP accumulation at 10 uM preincubated for 30 mins followed agonist addition measured after 30 to 60 mins | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4028342 | F | Antagonist activity at human XCR1 expressed in CHOK1 cells assessed as inhibition of lymphotactin-induced cAMP accumulation at 10 uM preincubated for 30 mins followed agonist addition measured after 30 to 60 mins | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4028343 | F | Antagonist activity at human CXCR1 expressed in CHOK1 cells assessed as inhibition of interleukin-8-induced cAMP accumulation at 10 uM preincubated for 30 mins followed agonist addition measured after 30 to 60 mins | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4028344 | F | Antagonist activity at human CXCR2 expressed in CHOK1 cells assessed as inhibition of interleukin-8-induced cAMP accumulation at 10 uM preincubated for 30 mins followed agonist addition measured after 30 to 60 mins | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4028345 | F | Antagonist activity at human CXCR3 expressed in CHOK1 cells assessed as inhibition of CXCL11-induced cAMP accumulation at 10 uM preincubated for 30 mins followed agonist addition measured after 30 to 60 mins | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4028346 | F | Antagonist activity at human CXCR4 expressed in CHOK1 cells assessed as inhibition of SDF1a-induced cAMP accumulation at 10 uM preincubated for 30 mins followed agonist addition measured after 30 to 60 mins | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4028347 | F | Antagonist activity at human CXCR5 expressed in CHOK1 cells assessed as inhibition of CXCL13-induced cAMP accumulation at 10 uM preincubated for 30 mins followed agonist addition measured after 30 to 60 mins | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4028348 | F | Antagonist activity at human CXCR6 at 10 uM preincubated for 30 mins followed agonist addition measured after 30 to 60 mins by cAMP assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 15. | ALA4028349 | B | Antagonist activity at CXCR4 in human CCRF-CEM cells assessed as inhibition of CXCL12-induced CXCR4+ cell migration pre-incubated for 10 mins before CXCL12 addition and measured after 2.5 hrs by flow cytometric analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4028350 | A | Cytotoxicity against human Detroit 551 cells | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4028351 | A | Cmax in C57BL/6 mouse at 6 mg/kg, sc measured up to 4 hrs post dose by LC-MS/MS analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 18. | ALA4028352 | A | Half life in C57BL/6 mouse at 6 mg/kg, sc measured up to 4 hrs post dose by LC-MS/MS analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 19. | ALA4028353 | A | AUC (0 to 4 hrs) in C57BL/6 mouse at 6 mg/kg, sc measured up to 4 hrs post dose by LC-MS/MS analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 20. | ALA4028354 | F | Induction hematopoietic stem cell mobilization in C57BL/6 mouse assessed as increase in CXCR4+ cells in blood at 35 mg/kg, sc measured after 2 hrs by APC-conjugated anti-CXCR4-staining based flow cytometry relative to vehicle control | Mus musculus | 1 | organism-based format | Scientific Literature |
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