| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4026980 | A | Apparent permeability in human Caco2 cells at 10 uM | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 2. | ALA4026981 | F | Induction of apoptosis in human OCI-LY10 cells assessed as caspase 3 cleavage at 0.3 to 3 uM after 6 to 24 hrs in presence of ibrutinib by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA4026982 | B | Inhibition of recombinant full length His-tagged human IRAK4 expressed in baculovirus expression system using 5-FAM-IPTSPITTTYFFFKKK-COOH as substrate after 240 mins in presence of ATP by mobility shift assay | Homo sapiens | 36 | assay format | Scientific Literature | ||
| 4. | ALA4026983 | B | Inhibition of IRAK4 in human KARPAS299 cells assessed as reduction in IL-1 stimulated IRAK4 phosphorylation at Thr345/Ser346 residues preincubated for 1 hr followed by IL-1 stimulation for 10 mins by flow cytometry analysis | Homo sapiens | 36 | cell-based format | Scientific Literature | ||
| 5. | ALA4026984 | P | Lipophilicity, log D of the compound at pH 7.4 by shake flask method | 36 | small-molecule physicochemical format | Scientific Literature | |||
| 6. | ALA4026985 | A | Intrinsic clearance in rat hepatocytes assessed per 10'6 cells | Rattus norvegicus | 27 | cell-based format | Scientific Literature | ||
| 7. | ALA4026986 | A | Efflux ratio of apparent permeability from basolateral to apical side over apical to basolateral side in human Caco2 cells at 10 uM | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 8. | ALA4026987 | P | Aqueous solubility of the compound at pH 7.4 at 25 degC | 2 | small-molecule physicochemical format | Scientific Literature | |||
| 9. | ALA4026988 | P | Stability of the compound assessed as compound hydrolysis at pH 1 to 10 | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 10. | ALA4026989 | A | Fraction unbound in mouse plasma | Mus musculus | 1 | cell-free format | Scientific Literature | ||
| 11. | ALA4026990 | A | Fraction unbound in rat plasma | Rattus norvegicus | 1 | cell-free format | Scientific Literature | ||
| 12. | ALA4026991 | A | Fraction unbound in dog plasma | Canis lupus familiaris | 1 | cell-free format | Scientific Literature | ||
| 13. | ALA4026992 | A | Fraction unbound in human plasma | Homo sapiens | 1 | cell-free format | Scientific Literature | ||
| 14. | ALA4026993 | A | Inhibition of CYP1A2 in human liver microsomes | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 15. | ALA4026994 | A | Inhibition of CYP2C9 in human liver microsomes | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 16. | ALA4026995 | A | Inhibition of CYP2C19 in human liver microsomes | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 17. | ALA4026996 | A | Inhibition of CYP2D6 in human liver microsomes | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 18. | ALA4026997 | A | Inhibition of CYP3A4 in human liver microsomes | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 19. | ALA4026998 | B | Inhibition of human hERG | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 20. | ALA4026999 | B | Inhibition of Nav1.5 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature |
The page will load shortly, Thanks for your patience!