| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4012390 | A | Volume of distribution in rat at 0.9 mg/kg, iv administered as single bolus dose | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 2. | ALA4012391 | A | Clearance in rat at 0.9 mg/kg, iv administered as single bolus dose | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 3. | ALA4012392 | B | Inhibition of recombinant full-length human N-terminal GST tagged KMO expressed in baculovirus infected Sf9 insect cell membranes using L-kynurenine as substrate measured after 2 hrs in presence of NADPH by RapidFire mass spectrometric method | Homo sapiens | 33 | assay format | Scientific Literature | ||
| 4. | ALA4012393 | B | Inhibition of full length human KMO expressed in HEK293 cells using L-kynurenine as substrate measured after 20 hrs by LC-MS/MS method | Homo sapiens | 14 | cell-based format | Scientific Literature | ||
| 5. | ALA4012394 | P | Lipophilicity, log D of the compound at pH 7.4 by chromatographic method | 14 | small-molecule physicochemical format | Scientific Literature | |||
| 6. | ALA4012395 | P | Aqueous solubility of the compound in PBS at pH 7.4 measured after 1 hr by chemiluminescent nitrogen detection method | 14 | small-molecule physicochemical format | Scientific Literature | |||
| 7. | ALA4012396 | A | Binding affinity to human serum albumin by HPLC analysis | Homo sapiens | 14 | single protein format | Scientific Literature | ||
| 8. | ALA4012397 | A | Fraction unbound in human plasma | Homo sapiens | 1 | cell-free format | Scientific Literature | ||
| 9. | ALA4012398 | P | Solubility of the compound in 0.9% NaCl | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 10. | ALA4012399 | B | Inhibition of IDO (unknown origin) at 100 uM | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 11. | ALA4012400 | B | Inhibition of TDO (unknown origin) at 100 uM | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 12. | ALA4012401 | B | Inhibition of KAT1 (unknown origin) at 100 uM | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 13. | ALA4012402 | B | Inhibition of KAT2 (unknown origin) at 100 uM | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 14. | ALA4012403 | B | Inhibition of Kynu (unknown origin) at 100 uM | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 15. | ALA4012404 | T | Mutagenicity in Salmonella typhimurium by Ames test in presence of S9 fraction | Salmonella enterica subsp. enterica serovar Typhimurium | 1 | assay format | Scientific Literature | ||
| 16. | ALA4012405 | T | Mutagenicity in Salmonella typhimurium by Ames test in absence of S9 fraction | Salmonella enterica subsp. enterica serovar Typhimurium | 1 | assay format | Scientific Literature | ||
| 17. | ALA4012406 | T | Mutagenicity in mouse L5178Y cells expressing wild-type TK+/- in presence of S9 fraction | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4012407 | A | Metabolic stability in microsomes (unknown origin) | Not specified | 1 | assay format | Scientific Literature | ||
| 19. | ALA4012408 | A | Metabolic stability in hepatocytes (unknown origin) assessed per million cells | Not specified | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA4012409 | A | Half life in rat at 0.9 mg/kg, iv administered as single bolus dose | Rattus norvegicus | 1 | organism-based format | Scientific Literature |
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