1. ALA4022894 B Corrector activity at HRP-fused CFTR F508del mutant (unknown origin) expressed in human CFBE41o cells assessed as increase in matured protein levels at cell surface after 18 to 24 hrs by luminescence assay Homo sapiens 15 ALA4020819 cell-based format Scientific Literature 2. ALA4022895 B Corrector activity at HRP-fused CFTR F508del mutant (unknown origin) expressed in human CFBE41o cells assessed as increase in matured protein levels at cell surface after 18 to 24 hrs by luminescence assay relative to 3-[(2R,4R)-4-({[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]-carbonyl}amino)-7-methoxy-3,4-dihydro-2H-chromen-2-yl]benzoic acid Homo sapiens 15 ALA4020819 cell-based format Scientific Literature 3. ALA4022896 P Lipophilicity, log D of the compound by HPLC method 20 ALA4020819 small-molecule physicochemical format Scientific Literature 4. ALA4022899 B Corrector activity at CFTR F508del/F508del mutant in primary HBE cells assessed as increase in chloride ion current across apical membrane at 3 uM measured 18 to 24 hrs post compound treatment on basolateral side of cells in presence of channel potentiator GLPG1837 by trans-epithelial current clamp method relative to control Homo sapiens 2 ALA4020819 cell-based format Scientific Literature 5. ALA4022900 P Permeability of the compound by PAMPA 4 ALA4020819 small-molecule physicochemical format Scientific Literature 6. ALA4022901 A Unbound intrinsic clearance in human hepatocytes Homo sapiens 11 ALA4020819 cell-based format Scientific Literature 7. ALA4022902 A Unbound intrinsic clearance in rat hepatocytes Rattus norvegicus 11 ALA4020819 cell-based format Scientific Literature 8. ALA4725212 T Incucyte cell viability with HEK293T Homo sapiens 1,713 ALA4689842 cell-based format EUbOPEN Chemogenomic Library 9. ALA4725213 T Incucyte cell viability with human fibroblast Homo sapiens 1,718 ALA4689842 cell-based format EUbOPEN Chemogenomic Library 10. ALA4725214 T Incucyte cell viability with U2OS Homo sapiens 1,712 ALA4689842 cell-based format EUbOPEN Chemogenomic Library 11. ALA4879555 B KinomeScan assay: inhibition of AAK1 Homo sapiens 108 ALA4507330 single protein format Donated Chemical Probes - SGC Frankfurt 12. ALA4879556 B KinomeScan assay: inhibition of ABL1(E255K)-phosphorylated Homo sapiens 108 ALA4507330 single protein format Donated Chemical Probes - SGC Frankfurt 13. ALA4879557 B KinomeScan assay: inhibition of ABL1(F317I)-nonphosphorylated Homo sapiens 108 ALA4507330 single protein format Donated Chemical Probes - SGC Frankfurt 14. ALA4879558 B KinomeScan assay: inhibition of ABL1(F317I)-phosphorylated Homo sapiens 108 ALA4507330 single protein format Donated Chemical Probes - SGC Frankfurt 15. ALA4879559 B KinomeScan assay: inhibition of ABL1(F317L)-nonphosphorylated Homo sapiens 108 ALA4507330 single protein format Donated Chemical Probes - SGC Frankfurt 16. ALA4879560 B KinomeScan assay: inhibition of ABL1(F317L)-phosphorylated Homo sapiens 108 ALA4507330 single protein format Donated Chemical Probes - SGC Frankfurt 17. ALA4879561 B KinomeScan assay: inhibition of ABL1(H396P)-nonphosphorylated Homo sapiens 108 ALA4507330 single protein format Donated Chemical Probes - SGC Frankfurt 18. ALA4879562 B KinomeScan assay: inhibition of ABL1(H396P)-phosphorylated Homo sapiens 108 ALA4507330 single protein format Donated Chemical Probes - SGC Frankfurt 19. ALA4879563 B KinomeScan assay: inhibition of ABL1(M351T)-phosphorylated Homo sapiens 108 ALA4507330 single protein format Donated Chemical Probes - SGC Frankfurt 20. ALA4879564 B KinomeScan assay: inhibition of ABL1(Q252H)-nonphosphorylated Homo sapiens 108 ALA4507330 single protein format Donated Chemical Probes - SGC Frankfurt