# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4020311 | B | Inhibition of Mycobacterium tuberculosis H37Rv N-terminal 6His-tagged LeuRS expressed in Escherichia coli BL21(DE3) assessed as L-[14C]leucine incorporation in to Escherichia coli tRNA after 20 mins by liquid scintillation counting analysis | Mycobacterium tuberculosis H37Rv | 44 | assay format | Scientific Literature | ||
2. | ALA4020312 | F | Antimicrobial activity against Mycobacterium tuberculosis H37Rv | Mycobacterium tuberculosis | 44 | assay format | Scientific Literature | ||
3. | ALA4020313 | A | Inhibition of human N-terminal 6His-tagged cytoplasmic LeuRS expressed in Escherichia coli BL21(DE3) assessed as L-[14C]leucine incorporation in to Escherichia coli tRNA after 20 mins by liquid scintillation counting analysis | Homo sapiens | 8 | assay format | Scientific Literature | ||
4. | ALA4020314 | T | Selectivity index, ratio of EC50 for inhibition of cytoplasmic LeuRS in HepG2 cells assessed as reduction in protein synthesis to MIC for Mycobacterium tuberculosis H37Rv | 8 | cell-based format | Scientific Literature | |||
5. | ALA4020315 | A | Inhibition of human N-terminal 6His-tagged mitochondrial LeuRS expressed in Escherichia coli BL21(DE3) assessed as L-[14C]leucine incorporation in to Escherichia coli tRNA after 20 mins by liquid scintillation counting analysis | Homo sapiens | 8 | assay format | Scientific Literature | ||
6. | ALA4020316 | A | Inhibition of cytoplasmic LeuRS in human HepG2 cells assessed as reduction in protein synthesis preincubated for 48 hrs followed by L-[14C]leucine addition measured after 3 hrs by liquid scintillation counting analysis | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
7. | ALA4020317 | A | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by CellTiter-Glo assay | Homo sapiens | 8 | cell-based format | Scientific Literature |