| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4029972 | B | Inhibition of human CYP11B2-CLE9 expressed in Chinese hamster V79 cells using 11-deoxycorticosterone as substrate preincubated for 1 hr followed by substrate addition measured for 3 hrs by HTRF assay | Homo sapiens | 31 | ALA4028827 | cell-based format | Scientific Literature | |
| 2. | ALA4029973 | A | Inhibition of human CYP11B1-8C7 expressed in Chinese hamster V79 cells using 11-deoxycortisol as substrate preincubated for 1 hr followed by substrate addition measured for 3 hrs by HTRF assay | Homo sapiens | 31 | ALA4028827 | cell-based format | Scientific Literature | |
| 3. | ALA4029974 | U | Selectivity ratio of IC50 for human CYP11B1-8C7 expressed in Chinese hamster V79 cells to IC50 for human CYP11B2-CLE9 expressed in Chinese hamster V79 cells | Homo sapiens | 31 | ALA4028827 | cell-based format | Scientific Literature | |
| 4. | ALA4029975 | B | Inhibition of rat CYP11B2-1F4 expressed in Chinese hamster V79 cells using 11-deoxycorticosterone as substrate preincubated for 1 hr followed by substrate addition measured for 3 hrs by HTRF assay | Rattus norvegicus | 5 | ALA4028827 | cell-based format | Scientific Literature | |
| 5. | ALA4029976 | B | Inhibition of human CYP17 expressed in African green monkey COS7 cells using 17-hydroxypregnenolone as substrate preincubated for 1 hr followed by substrate addition measured after 3 hrs by EIA | Homo sapiens | 5 | ALA4028827 | cell-based format | Scientific Literature | |
| 6. | ALA4029977 | B | Inhibition of CYP19 (unknown origin) using MFC as substrate and NADPH as cofactor preincubated for 10 mins with cofactor followed by substrate/enzyme addition measured after 30 mins | Homo sapiens | 5 | ALA4028827 | single protein format | Scientific Literature | |
| 7. | ALA4029978 | B | Inhibition of human CYP21 expressed in African green monkey COS7 cells using 17-hydroxypregnenolone as substrate preincubated for 1 hr followed by substrate addition measured for 3 hrs by HTRF assay | Homo sapiens | 5 | ALA4028827 | cell-based format | Scientific Literature | |
| 8. | ALA4029979 | A | Inhibition of hepatic CYP3A4 (unknown origin) | Homo sapiens | 5 | ALA4028827 | single protein format | Scientific Literature | |
| 9. | ALA4029980 | A | Inhibition of hepatic CYP2C9 (unknown origin) | Homo sapiens | 5 | ALA4028827 | single protein format | Scientific Literature | |
| 10. | ALA4029981 | A | Inhibition of hepatic CYP2D6 (unknown origin) | Homo sapiens | 5 | ALA4028827 | single protein format | Scientific Literature | |
| 11. | ALA4029982 | A | Intrinsic clearance in rat liver microsomes at 0.3 mM preincubated for 10 mins followed by NADPH addition measured after 45 mins by LC-MS analysis | Rattus norvegicus | 23 | ALA4028827 | assay format | Scientific Literature | |
| 12. | ALA4029983 | A | Volume of distribution in Sprague-Dawley rat at 1 mg/kg, iv or 2 mg/kg, po administered via gavage by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4028827 | organism-based format | Scientific Literature | |
| 13. | ALA4029984 | A | Oral bioavailability in Sprague-Dawley rat at 2 mg/kg administered via gavage by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4028827 | organism-based format | Scientific Literature | |
| 14. | ALA4029985 | A | Dose normalized AUC in Sprague-Dawley rat at 2 mg/kg, po administered via gavage by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4028827 | organism-based format | Scientific Literature | |
| 15. | ALA4029986 | A | Plasma clearance in Sprague-Dawley rat at 1 mg/kg, iv or 2 mg/kg, po administered via gavage by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4028827 | organism-based format | Scientific Literature | |
| 16. | ALA4029987 | A | Half life in Sprague-Dawley rat at 1 mg/kg, iv or 2 mg/kg, po administered via gavage by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4028827 | organism-based format | Scientific Literature | |
| 17. | ALA4029988 | B | Selectivity ratio of IC50 for CYP19 (unknown origin) to IC50 for human CYP11B2-CLE9 expressed in Chinese hamster V79 cells | Homo sapiens | 1 | ALA4028827 | cell-based format | Scientific Literature | |
| 18. | ALA4029989 | U | Selectivity ratio of IC50 for hepatic CYP2D6 (unknown origin) to IC50 for human CYP11B2-CLE9 expressed in Chinese hamster V79 cells | Homo sapiens | 1 | ALA4028827 | cell-based format | Scientific Literature | |
| 19. | ALA4029990 | U | Selectivity ratio of IC50 for hepatic CYP2C9 (unknown origin) to IC50 for human CYP11B2-CLE9 expressed in Chinese hamster V79 cells | Homo sapiens | 1 | ALA4028827 | cell-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!