| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4012157 | A | Plasma protein binding in Beagle dog | Canis lupus familiaris | 5 | cell-free format | Scientific Literature | ||
| 2. | ALA4012158 | P | Aqueous solubility of the compound at pH 2 | 36 | small-molecule physicochemical format | Scientific Literature | |||
| 3. | ALA4012159 | P | Aqueous solubility of the compound at pH 7 | 36 | small-molecule physicochemical format | Scientific Literature | |||
| 4. | ALA4012160 | A | Clearance in Beagle dog at 0.5 mg/kg, iv or 1 mg/kg, po | Canis lupus familiaris | 5 | organism-based format | Scientific Literature | ||
| 5. | ALA4012161 | A | Volume of distribution in Beagle dog at 0.5 mg/kg, iv or 1 mg/kg, po | Canis lupus familiaris | 5 | organism-based format | Scientific Literature | ||
| 6. | ALA4012162 | B | Ratio of IP for inhibition of HIV-1 integrase E92Q mutant strand transfer activity to IP for inhibition of wild-type HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% normal human serum | Human immunodeficiency virus 1 | 33 | assay format | Scientific Literature | ||
| 7. | ALA4012163 | A | Half life in Beagle dog at 0.5 mg/kg, iv or 1 mg/kg, po | Canis lupus familiaris | 5 | organism-based format | Scientific Literature | ||
| 8. | ALA4012164 | A | Oral bioavailability in Beagle dog at 1 mg/kg | Canis lupus familiaris | 5 | organism-based format | Scientific Literature | ||
| 9. | ALA4012166 | B | Inhibition of wild-type HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% normal human serum | Human immunodeficiency virus 1 | 38 | assay format | Scientific Literature | ||
| 10. | ALA4012167 | B | Inhibition of HIV-1 integrase E92Q mutant strand transfer activity assessed as reduction in viral replication | Human immunodeficiency virus 1 | 5 | assay format | Scientific Literature | ||
| 11. | ALA4012168 | B | Inhibition of HIV-1 integrase Y143R mutant strand transfer activity assessed as reduction in viral replication | Human immunodeficiency virus 1 | 5 | assay format | Scientific Literature | ||
| 12. | ALA4012169 | B | Inhibition of HIV-1 integrase Q148R mutant strand transfer activity assessed as reduction in viral replication | Human immunodeficiency virus 1 | 5 | assay format | Scientific Literature | ||
| 13. | ALA4012170 | B | Inhibition of HIV-1 integrase Q148K mutant strand transfer activity assessed as reduction in viral replication | Human immunodeficiency virus 1 | 5 | assay format | Scientific Literature | ||
| 14. | ALA4012171 | B | Inhibition of HIV-1 integrase N155H mutant strand transfer activity assessed as reduction viral replication | Human immunodeficiency virus 1 | 5 | assay format | Scientific Literature | ||
| 15. | ALA4012172 | B | Inhibition of HIV-1 integrase G140S/Q148H double mutant strand transfer activity assessed as reduction in viral replication | Human immunodeficiency virus 1 | 5 | assay format | Scientific Literature | ||
| 16. | ALA4012173 | B | Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 50% normal human serum | Human immunodeficiency virus 1 | 38 | assay format | Scientific Literature | ||
| 17. | ALA4012174 | B | Ratio of IP for inhibition of HIV-1 integrase Y143R mutant strand transfer activity to IP for inhibition of wild-type HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% normal human serum | Human immunodeficiency virus 1 | 33 | assay format | Scientific Literature | ||
| 18. | ALA4012175 | B | Ratio of IP for inhibition of HIV-1 integrase Q148R mutant strand transfer activity to IP for inhibition of wild-type HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% normal human serum | Human immunodeficiency virus 1 | 33 | assay format | Scientific Literature | ||
| 19. | ALA4012176 | B | Ratio of IP for inhibition of HIV-1 integrase Q148K mutant strand transfer activity to IP for inhibition of wild-type HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% normal human serum | Human immunodeficiency virus 1 | 33 | assay format | Scientific Literature | ||
| 20. | ALA4012177 | B | Ratio of IP for inhibition of HIV-1 integrase N155H mutant strand transfer activity to IP for inhibition of wild-type HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% normal human serum | Human immunodeficiency virus 1 | 33 | assay format | Scientific Literature |
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