# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4035162 | Binding | Inhibition of IL-6 signaling pathway in human HepG2 cells transfected with p-STAT3-Luc assessed as reduction in IL-6 induced STAT3 phosphorylation at 20 ug/ml preincubated for 1 hr followed by IL-6 induction measured after 10 mins by immunoblot analysis | Homo sapiens | 16 | ALA4033664 | cell-based format | Scientific Literature | |
2. | ALA4035167 | Functional | Antiinflammatory activity in C57BL6 mouse CD4-positive T-effector Th17 cells assessed as suppression of IL-17 levels at 10 uM preincubated for 3 to 4 days followed by anti-CD3 stimulation for 24 hrs by ELISA | Mus musculus | 2 | ALA4033664 | cell-based format | Scientific Literature | |
3. | ALA4035168 | ADME | Proinflammatory activity in C57BL6 mouse CD4-positive T-effector Th1 cells assessed as increase in anti-CD3/IL-12-induced IL-2 levels at 10 uM preincubated for 3 to 4 days followed by anti-CD3 stimulation for 24 hrs by ELISA | Mus musculus | 1 | ALA4033664 | cell-based format | Scientific Literature | |
4. | ALA4035169 | ADME | Proinflammatory activity in C57BL6 mouse CD4-positive T-effector Th1 cells assessed as increase in anti-CD3/IL-12-induced IFNgamma levels at 10 uM preincubated for 3 to 4 days followed by anti-CD3 stimulation for 24 hrs by ELISA | Mus musculus | 1 | ALA4033664 | cell-based format | Scientific Literature | |
5. | ALA4035170 | Functional | Antiinflammatory activity in C57BL6 mouse CD4-positive T-effector TH2 cells assessed as suppression of IL-4 levels at 10 uM preincubated for 3 to 4 days followed by anti-CD3 stimulation for 24 hrs by ELISA | Mus musculus | 2 | ALA4033664 | cell-based format | Scientific Literature | |
6. | ALA4035171 | Functional | Antiinflammatory activity in C57BL6 mouse CD4-positive T-effector TH2 cells assessed as suppression of IL-5 levels at 10 uM preincubated for 3 to 4 days followed by anti-CD3 stimulation for 24 hrs by ELISA | Mus musculus | 2 | ALA4033664 | cell-based format | Scientific Literature | |
7. | ALA4035172 | Functional | Antiinflammatory activity in C57BL6 mouse CD4-positive T-effector TH2 cells assessed as suppression of IL-13 levels at 10 uM preincubated for 3 to 4 days followed by anti-CD3 stimulation for 24 hrs by ELISA | Mus musculus | 2 | ALA4033664 | cell-based format | Scientific Literature |