| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4034608 | B | Inhibition of DNMT1 (unknown origin) at 100 uM using poly(dI-dC).poly(dI-dC) as substrate preincubated for 15 mins followed by substrate/[3H]-SAM addition measured after 120 mins by liquid scintillation counting analysis | Homo sapiens | 12 | ALA4033641 | single protein format | Scientific Literature | |
| 2. | ALA4034609 | B | Inhibition of DNMT3A/3L (unknown origin) at 100 uM using biotinylated DNA oligonucleotides as substrate preincubated for 15 mins followed by substrate/[3H]-SAM addition measured after 4 hrs by liquid scintillation counting analysis | Homo sapiens | 12 | ALA4033641 | protein complex format | Scientific Literature | |
| 3. | ALA4034610 | B | Inhibition of DNMT3B/3L (unknown origin) at 100 uM using biotinylated DNA oligonucleotides as substrate preincubated for 15 mins followed by substrate/[3H]-SAM addition measured after 4 hrs by liquid scintillation counting analysis | Homo sapiens | 12 | ALA4033641 | protein complex format | Scientific Literature | |
| 4. | ALA4034611 | B | Inhibition of HDAC1 (unknown origin) preincubated for 15 mins followed by substrate addition measured after 60 mins by fluorescence assay | Homo sapiens | 12 | ALA4033641 | single protein format | Scientific Literature | |
| 5. | ALA4034612 | B | Inhibition of HDAC6 (unknown origin) preincubated for 15 mins followed by substrate addition measured after 60 mins by fluorescence assay | Homo sapiens | 12 | ALA4033641 | single protein format | Scientific Literature | |
| 6. | ALA4034613 | F | Antiproliferative activity against human K562 cells after 72 hrs by MTT assay | Homo sapiens | 13 | ALA4033641 | cell-based format | Scientific Literature | |
| 7. | ALA4034614 | F | Antiproliferative activity against human U937 cells after 72 hrs by MTT assay | Homo sapiens | 12 | ALA4033641 | cell-based format | Scientific Literature | |
| 8. | ALA4034629 | F | Induction of apoptosis in human U937 cells assessed as necrotic cells at 2.5 uM after 48 hrs by Annexin V-FITC/PI staining based flow cytometry (Rvb = 0%) | Homo sapiens | 2 | ALA4033641 | cell-based format | Scientific Literature | |
| 9. | ALA4034630 | B | Inhibition of HDAC in human U937 cells assessed as induction of histone H3K9 acetylation after 12 hrs by Western blot analysis | Homo sapiens | 1 | ALA4033641 | cell-based format | Scientific Literature | |
| 10. | ALA4034631 | B | Inhibition of HDAC in human U937 cells assessed as induction of histone H4K8 acetylation after 12 hrs by Western blot analysis | Homo sapiens | 1 | ALA4033641 | cell-based format | Scientific Literature | |
| 11. | ALA4034632 | B | Inhibition of DNMT1 in human U937 cells assessed as increase in P16INK4A expression level at 1 to 5 uM after 36 hrs by Western blot analysis | Homo sapiens | 1 | ALA4033641 | cell-based format | Scientific Literature | |
| 12. | ALA4034633 | B | Inhibition of DNMT in human U937 cells assessed as induction of P16 CpG islands demethylation at 1 to 2.5 uM after 36 hrs by PCR analysis | Homo sapiens | 1 | ALA4033641 | cell-based format | Scientific Literature | |
| 13. | ALA4034634 | F | Induction of apoptosis in human U937 cells assessed as increase in cleaved caspase-3 level at 1 to 5 uM after 36 hrs by Western blot analysis | Homo sapiens | 1 | ALA4033641 | cell-based format | Scientific Literature | |
| 14. | ALA4034635 | F | Induction of apoptosis in human U937 cells assessed as increase in cleaved PARP expression at 1 to 5 uM after 36 hrs by Western blot analysis | Homo sapiens | 1 | ALA4033641 | cell-based format | Scientific Literature | |
| 15. | ALA4034636 | F | Induction of apoptosis in human U937 cells assessed as increase in PARP expression at 1 to 5 uM after 36 hrs by Western blot analysis | Homo sapiens | 1 | ALA4033641 | cell-based format | Scientific Literature | |
| 16. | ALA4034637 | F | Induction of apoptosis in human U937 cells assessed as viable cells at 2.5 uM after 48 hrs by Annexin V-FITC/PI staining based flow cytometry (Rvb = 99.4%) | Homo sapiens | 1 | ALA4033641 | cell-based format | Scientific Literature | |
| 17. | ALA4034638 | F | Induction of apoptosis in human U937 cells assessed as early apoptotic cells at 2.5 uM after 48 hrs by Annexin V-FITC/PI staining based flow cytometry (Rvb = 0.162%) | Homo sapiens | 1 | ALA4033641 | cell-based format | Scientific Literature | |
| 18. | ALA4034639 | F | Induction of apoptosis in human U937 cells assessed as late apoptotic cells at 2.5 uM after 48 hrs by Annexin V-FITC/PI staining based flow cytometry (Rvb = 0.438%) | Homo sapiens | 1 | ALA4033641 | cell-based format | Scientific Literature | |
| 19. | ALA4034640 | F | Induction of apoptosis in human U937 cells assessed as viable cells at 5 uM after 48 hrs by Annexin V-FITC/PI staining based flow cytometry (Rvb = 99.4%) | Homo sapiens | 1 | ALA4033641 | cell-based format | Scientific Literature | |
| 20. | ALA4034641 | F | Induction of apoptosis in human U937 cells assessed as early apoptotic cells at 5 uM after 48 hrs by Annexin V-FITC/PI staining based flow cytometry (Rvb = 0.162%) | Homo sapiens | 1 | ALA4033641 | cell-based format | Scientific Literature |
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