# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4051035 | B | Agonist activity at recombinant human beta3 adrenergic receptor expressed in CHO cells assessed as accumulation of cyclic AMP after 30 mins | Homo sapiens | 14 | ALA4049422 | cell-based format | Scientific Literature | |
2. | ALA4051036 | B | Intrinsic activity at recombinant human beta3 adrenergic receptor expressed in CHO cells assessed as accumulation of cyclic AMP after 30 mins relative to isoproterenol | Homo sapiens | 10 | ALA4049422 | cell-based format | Scientific Literature | |
3. | ALA4051037 | A | Agonist activity at recombinant human alpha1A adrenergic receptor expressed in HEK293 cells assessed as intercellular Ca mobilization by Fura-2AM dye-based fluorescence assay | Homo sapiens | 12 | ALA4049422 | cell-based format | Scientific Literature | |
4. | ALA4051038 | A | Intrinsic activity at recombinant human alpha1A adrenergic receptor expressed in HEK293 cells assessed as intercellular Ca mobilization by Fura-2AM dye-based fluorescence assay relative to norepinephrine | Homo sapiens | 10 | ALA4049422 | cell-based format | Scientific Literature | |
5. | ALA4051039 | U | Selectivity ratio of EC50 for recombinant human alpha1A adrenergic receptor to EC50 for recombinant human beta3 adrenergic receptor | Homo sapiens | 10 | ALA4049422 | assay format | Scientific Literature | |
6. | ALA4051040 | A | Intrinsic clearance in human liver microsomes at 1 uM in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 6 | ALA4049422 | assay format | Scientific Literature | |
7. | ALA4051041 | A | Intrinsic clearance in Sprague-Dawley rat liver microsomes at 0.5 uM in presence of NADPH by LC-MS/MS analysis | Rattus norvegicus | 6 | ALA4049422 | assay format | Scientific Literature | |
8. | ALA4051042 | P | Solubility of the compound at pH 1.2 buffer solution after 18 hrs by HPLC analysis | 4 | ALA4049422 | small-molecule physicochemical format | Scientific Literature | ||
9. | ALA4051043 | P | Solubility of the compound at pH 6.8 buffer solution after 18 hrs by HPLC analysis | 4 | ALA4049422 | small-molecule physicochemical format | Scientific Literature | ||
10. | ALA4051044 | A | Cmax in Sprague-Dawley rat at 5 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 4 | ALA4049422 | organism-based format | Scientific Literature | |
11. | ALA4051045 | A | AUC in Sprague-Dawley rat at 5 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 4 | ALA4049422 | organism-based format | Scientific Literature | |
12. | ALA4051046 | A | Half life in Sprague-Dawley rat at 5 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 3 | ALA4049422 | organism-based format | Scientific Literature | |
13. | ALA4051047 | A | Membrane permeability in MDCK cells at 50 uM after 60 mins by LC-MS/MS analysis | Canis lupus familiaris | 4 | ALA4049422 | cell-based format | Scientific Literature | |
14. | ALA4051048 | A | Agonist activity at recombinant human beta1 adrenergic receptor expressed in CHO cells assessed as accumulation of cyclic AMP after 30 mins | Homo sapiens | 5 | ALA4049422 | cell-based format | Scientific Literature | |
15. | ALA4051049 | A | Intrinsic activity at recombinant human beta1 adrenergic receptor assessed as accumulation of cyclic AMP after 30 mins relative to norepinephrine | Homo sapiens | 3 | ALA4049422 | single protein format | Scientific Literature | |
16. | ALA4051050 | A | Agonist activity at recombinant human beta2 adrenergic receptor expressed in CHO cells assessed as accumulation of cyclic AMP after 30 mins | Homo sapiens | 5 | ALA4049422 | cell-based format | Scientific Literature | |
17. | ALA4051051 | A | Intrinsic activity at recombinant human beta2 adrenergic receptor assessed as accumulation of cyclic AMP after 30 mins relative to norepinephrine | Homo sapiens | 3 | ALA4049422 | single protein format | Scientific Literature | |
18. | ALA4051052 | A | Inhibition of CYP1A2 (unknown origin) at 10 uM relative to control | Homo sapiens | 1 | ALA4049422 | single protein format | Scientific Literature | |
19. | ALA4051053 | A | Inhibition of CYP2B6 (unknown origin) at 10 uM relative to control | Homo sapiens | 1 | ALA4049422 | single protein format | Scientific Literature | |
20. | ALA4051054 | A | Inhibition of CYP2C19 (unknown origin) at 10 uM relative to control | Homo sapiens | 1 | ALA4049422 | single protein format | Scientific Literature |