# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4026494 | B | Inhibition of rat His-tagged PRMT1 (11 to 353 residues) expressed in Escherichia coli BL21(DE3) using biotinylated H4 peptide (1 to 21 residues) as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in presence of [3H]SAM by microbeta counting method | Rattus norvegicus | 18 | ALA4024748 | assay format | Scientific Literature | |
2. | ALA4026533 | F | Cytotoxicity against human MV4-11 cells assessed as decrease in cell viability at 6.25 to 12.5 uM after 96 hrs by Cell-Titer Glo assay | Homo sapiens | 3 | ALA4024748 | cell-based format | Scientific Literature | |
3. | ALA4026541 | B | Inhibition of PRMT1 in human MV411 cells assessed as reduction in arginine methylation after 48 hrs by Western blot analysis | Homo sapiens | 1 | ALA4024748 | cell-based format | Scientific Literature | |
4. | ALA4026553 | F | Cell cycle arrest in human MV4-11 cells assessed as accumulation at G1 phase at 1.67 to 15 uM after 72 hrs by propidium iodide staining-based flow cytometry | Homo sapiens | 1 | ALA4024748 | cell-based format | Scientific Literature | |
5. | ALA4026554 | F | Induction of apoptosis in human MV4-11 cells up to 15 uM after 96 hrs by annexin V-FITC/propidium iodide staining-based flow cytometric method | Homo sapiens | 1 | ALA4024748 | cell-based format | Scientific Literature | |
6. | ALA4026555 | F | Downregulation of HOXA9 mRNA levels in human MV4-11 cells up to 15 uM by qRT-PCR analysis | Homo sapiens | 1 | ALA4024748 | cell-based format | Scientific Literature | |
7. | ALA4026556 | F | Downregulation of HOXA10 mRNA levels in human MV4-11 cells up to 15 uM by qRT-PCR analysis | Homo sapiens | 1 | ALA4024748 | cell-based format | Scientific Literature | |
8. | ALA4026557 | F | Downregulation of MEIS1 mRNA levels in human MV4-11 cells up to 15 uM by qRT-PCR analysis | Homo sapiens | 1 | ALA4024748 | cell-based format | Scientific Literature |