| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4019021 | B | Inhibition of human MMP2 (Tyr110 to Asp452 residues) expressed in yeast at 50 to 100 uM using Mca-Pro-LeuGly-Leu-Dpa-Ala-Arg-NH2.AcOH as substrate preincubated for 30 mins followed by substrate addition measured after 20 mins by fluorescence assay relative to control | Homo sapiens | 1 | ALA4017500 | assay format | Scientific Literature | |
| 2. | ALA4019025 | B | Inhibition of bacterial MBP-fused NDM1 expressed in Escherichia coli BL21(DE3) ausing chromacef as substrate preincubated for 20 mins followed by substrate addition measured after 0.3 mins | Bacteria | 44 | ALA4017500 | assay format | Scientific Literature | |
| 3. | ALA4019026 | B | Inhibition of bacterial MBP-fused NDM1 expressed in Escherichia coli BL21(DE3) ausing fluorocillin as substrate preincubated for 20 mins followed by substrate addition measured at 1 sec time interval for 25 mins by fluorescence assay | Bacteria | 15 | ALA4017500 | assay format | Scientific Literature | |
| 4. | ALA4019027 | B | Inhibition of bacterial MBP-fused NDM1 expressed in Escherichia coli BL21(DE3) ausing fluorocillin as substrate preincubated for 20 mins followed by substrate addition measured at 1 sec time interval for 25 mins in presence of ZnSO4 by fluorescence assay | Bacteria | 2 | ALA4017500 | assay format | Scientific Literature | |
| 5. | ALA4019028 | B | Inhibition of Serratia marcescens IMP1 expressed in Escherichia coli BL21(DE3) using chromacef as substrate preincubated for 10 mins followed by substrate addition measured after 20 mins by HTS assay | Serratia marcescens | 2 | ALA4017500 | assay format | Scientific Literature | |
| 6. | ALA4019029 | B | Inhibition of Pseudomonas aeruginosa VIM2 expressed in Escherichia coli BL21(DE3) using chromacef as substrate preincubated for 10 mins followed by substrate addition measured after 20 mins by HTS assay | Pseudomonas aeruginosa | 2 | ALA4017500 | assay format | Scientific Literature | |
| 7. | ALA4019030 | B | Inhibition of human MMP2 (Tyr110 to Asp452 residues) expressed in yeast at 10 uM using Mca-Pro-LeuGly-Leu-Dpa-Ala-Arg-NH2.AcOH as substrate preincubated for 30 mins followed by substrate addition measured after 20 mins by fluorescence assay relative to control | Homo sapiens | 1 | ALA4017500 | assay format | Scientific Literature | |
| 8. | ALA4019031 | B | Inhibition of human MMP12 (Phe99 to Leu271 residues) expressed in Escherichia coli at 10 uM using Mca-Pro-LeuGly-Leu-Dpa-Ala-Arg-NH2.AcOH as substrate preincubated for 30 mins followed by substrate addition measured after 20 mins by fluorescence assay relative to control | Homo sapiens | 1 | ALA4017500 | assay format | Scientific Literature | |
| 9. | ALA4019032 | B | Inhibition of full length human C-terminal FLAG/His-tagged HDAC1 expressed in baculovirus infected sf9 cells at 10 uM using HDAC substrate 3 preincubated for 5 mins followed by substrate addition measured after 30 mins by fluorescence assay | Homo sapiens | 1 | ALA4017500 | cell-based format | Scientific Literature | |
| 10. | ALA4019033 | B | Inhibition of full length human N-terminal GST-tagged HDAC6 expressed in baculovirus infected sf9 cells at 10 uM using HDAC substrate 3 preincubated for 5 mins followed by substrate addition measured after 30 mins by fluorescence assay | Homo sapiens | 1 | ALA4017500 | cell-based format | Scientific Literature | |
| 11. | ALA4019034 | B | Inhibition of human carbonic anhydrase 2 at 10 uM using p-nitrophenyl acetate as substrate preincubated for 10 mins followed by substrate addition measured for 15 mins | Homo sapiens | 1 | ALA4017500 | single protein format | Scientific Literature | |
| 12. | ALA4019035 | B | Inhibition of human MMP12 (Phe99 to Leu271 residues) expressed in Escherichia coli at 50 to 100 uM using Mca-Pro-LeuGly-Leu-Dpa-Ala-Arg-NH2.AcOH as substrate preincubated for 30 mins followed by substrate addition measured after 20 mins by fluorescence assay relative to control | Homo sapiens | 1 | ALA4017500 | assay format | Scientific Literature | |
| 13. | ALA4019036 | B | Inhibition of full length human C-terminal FLAG/His-tagged HDAC1 expressed in baculovirus infected sf9 cells at 50 to 100 uM using HDAC substrate 3 preincubated for 5 mins followed by substrate addition measured after 30 mins by fluorescence assay | Homo sapiens | 1 | ALA4017500 | cell-based format | Scientific Literature | |
| 14. | ALA4019037 | B | Inhibition of full length human N-terminal GST-tagged HDAC6 expressed in baculovirus infected sf9 cells at 50 to 100 uM using HDAC substrate 3 preincubated for 5 mins followed by substrate addition measured after 30 mins by fluorescence assay | Homo sapiens | 1 | ALA4017500 | cell-based format | Scientific Literature | |
| 15. | ALA4019038 | B | Inhibition of human carbonic anhydrase 2 at 50 to 100 uM using p-nitrophenyl acetate as substrate preincubated for 10 mins followed by substrate addition measured for 15 mins | Homo sapiens | 1 | ALA4017500 | single protein format | Scientific Literature | |
| 16. | ALA4019039 | B | Selectivity ratio of compound effect for inhibition of bacterial MBP-fused NDM1 expressed in Escherichia coli BL21(DE3) to compound effect for inhibition of human MMP2 (Tyr110 to Asp452 residues) expressed in yeast | 1 | ALA4017500 | assay format | Scientific Literature | ||
| 17. | ALA4019040 | B | Selectivity ratio of compound effect for inhibition of bacterial MBP-fused NDM1 expressed in Escherichia coli BL21(DE3) to compound effect for inhibition of human MMP12 (Phe99 to Leu271 residues) expressed in Escherichia coli | 1 | ALA4017500 | assay format | Scientific Literature | ||
| 18. | ALA4019041 | B | Selectivity ratio of compound effect for inhibition of bacterial MBP-fused NDM1 expressed in Escherichia coli BL21(DE3) to compound effect for inhibition of full length human C-terminal FLAG/His-tagged HDAC1 expressed in baculovirus infected sf9 cells | 1 | ALA4017500 | cell-based format | Scientific Literature | ||
| 19. | ALA4019042 | B | Selectivity ratio of compound effect for inhibition of bacterial MBP-fused NDM1 expressed in Escherichia coli BL21(DE3) to compound effect for inhibition of full length human N-terminal GST-tagged HDAC6 expressed in baculovirus infected sf9 cells | 1 | ALA4017500 | cell-based format | Scientific Literature | ||
| 20. | ALA4019043 | B | Selectivity ratio of compound effect for inhibition of bacterial MBP-fused NDM1 expressed in Escherichia coli BL21(DE3) to compound effect for inhibition of human carbonic anhydrase 2 | 1 | ALA4017500 | assay format | Scientific Literature |
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