# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4035162 | B | Inhibition of IL-6 signaling pathway in human HepG2 cells transfected with p-STAT3-Luc assessed as reduction in IL-6 induced STAT3 phosphorylation at 20 ug/ml preincubated for 1 hr followed by IL-6 induction measured after 10 mins by immunoblot analysis | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
2. | ALA4035163 | B | Inhibition of IL-6 signaling pathway in human HepG2 cells transfected with p-STAT3-Luc assessed as reduction in IL-6 induced STAT3 phosphorylation preincubated for 1 hr followed by IL-6 induction measured after 10 mins by immunoblot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
3. | ALA4035164 | A | Cytotoxicity against human HepG2 cells assessed as cell viability at 10 ug/ml after 48 hrs by MTT assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
4. | ALA4035165 | F | Antiinflammatory activity in C57BL6 mouse CD4-positive T-effector Th1 cells assessed as suppression of anti-CD3/IL-12-induced IL-2 levels at 10 uM preincubated for 3 to 4 days followed by anti-CD3 stimulation for 24 hrs by ELISA | Mus musculus | 1 | cell-based format | Scientific Literature | ||
5. | ALA4035166 | F | Antiinflammatory activity in C57BL6 mouse CD4-positive T-effector Th1 cells assessed as suppression of anti-CD3/IL-12-induced IFNgamma levels at 10 uM preincubated for 3 to 4 days followed by anti-CD3 stimulation for 24 hrs by ELISA | Mus musculus | 1 | cell-based format | Scientific Literature | ||
6. | ALA4035167 | F | Antiinflammatory activity in C57BL6 mouse CD4-positive T-effector Th17 cells assessed as suppression of IL-17 levels at 10 uM preincubated for 3 to 4 days followed by anti-CD3 stimulation for 24 hrs by ELISA | Mus musculus | 2 | cell-based format | Scientific Literature | ||
7. | ALA4035170 | F | Antiinflammatory activity in C57BL6 mouse CD4-positive T-effector TH2 cells assessed as suppression of IL-4 levels at 10 uM preincubated for 3 to 4 days followed by anti-CD3 stimulation for 24 hrs by ELISA | Mus musculus | 2 | cell-based format | Scientific Literature | ||
8. | ALA4035171 | F | Antiinflammatory activity in C57BL6 mouse CD4-positive T-effector TH2 cells assessed as suppression of IL-5 levels at 10 uM preincubated for 3 to 4 days followed by anti-CD3 stimulation for 24 hrs by ELISA | Mus musculus | 2 | cell-based format | Scientific Literature | ||
9. | ALA4035172 | F | Antiinflammatory activity in C57BL6 mouse CD4-positive T-effector TH2 cells assessed as suppression of IL-13 levels at 10 uM preincubated for 3 to 4 days followed by anti-CD3 stimulation for 24 hrs by ELISA | Mus musculus | 2 | cell-based format | Scientific Literature | ||
10. | ALA4627703 | B | Inhibition of STAT3 in human K562 cells assessed as reduction in STAT3 phosphorylation | Homo sapiens | 2 | cell-based format | Scientific Literature |