| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4052329 | B | Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs followed by substrate addition measured every 2 mins for 1 hr by amplex red reagent-based fluorescence assay | Homo sapiens | 30 | cell-based format | Scientific Literature | ||
| 2. | ALA4052332 | B | Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs followed by substrate addition in presence of 0.1% BSA measured every 2 mins for 1 hr by amplex red reagent-based fluorescence assay | Homo sapiens | 30 | cell-based format | Scientific Literature | ||
| 3. | ALA4052333 | B | Inhibition of human LOX expressed in HEK cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs followed by substrate addition in presence of 0.1% BSA measured every 2 mins for 1 hr by amplex red reagent-based fluorescence assay | Homo sapiens | 30 | cell-based format | Scientific Literature | ||
| 4. | ALA4052334 | B | Inhibition of recombinant human LOXL2 expressed in human whole blood assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs followed by substrate addition measured every 2 mins for 1 hr by amplex red reagent-based fluorescence assay | Homo sapiens | 30 | assay format | Scientific Literature | ||
| 5. | ALA4052335 | A | Cmax in C57BL/6 mouse lung at 30 mg/kg, po by LC-MS/MS analysis | Mus musculus | 12 | organism-based format | Scientific Literature | ||
| 6. | ALA4052336 | A | Cmax in C57BL/6 mouse plasma at 30 mg/kg, po by LC-MS/MS analysis | Mus musculus | 12 | organism-based format | Scientific Literature | ||
| 7. | ALA4052342 | B | Selectivity ratio of IC50 for human LOX expressed in HEK cells in presence of 0.1% BSA to IC50 for human LOXL2 expressed in CHO cells in presence of 0.1% BSA | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 8. | ALA4418378 | B | Inhibition of human LOXL2 expressed in CHO cells assessed as reduction in amine oxidase activity incubated for 2 hrs by Amplex red based fluorescence assay | Homo sapiens | 120 | cell-based format | Patent Bioactivity Data |
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