| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4050836 | A | Drug metabolism in pH 7.4 trizma buffer assessed as cathepsin A (unknown origin)-mediated (S)-2-((((2R,3S,4R,5R)-5-(6-(furan-2-ylmethylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)oxidophosphorylamino)propanoate formation at 5.0 mg measured after 2 to 12 hrs by 31P-NMR spectroscopic analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 2. | ALA4050837 | A | Metabolic stability of compound in human serum at 5.0 mg measured at even intervals over 11 hrs by 31P-NMR spectroscopic analysis | Homo sapiens | 1 | cell-free format | Scientific Literature | ||
| 3. | ALA4050838 | A | Metabolic stability of the compound in mouse serum at 5.0 mg measured at even intervals over 11 hrs by 31P-NMR spectroscopic analysis | Mus musculus | 1 | cell-free format | Scientific Literature | ||
| 4. | ALA4050839 | P | Chemical stability of compound in pH 1 buffer at 5.0 mg measured at every 20 mins over 12 hrs by 31P-NMR spectroscopic analysis | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 5. | ALA4050840 | B | Activation of FLAG tagged PINK1 (unknown origin) expressed in Flp-In TRex HEK293 cells co-expressing wild-type Parkin assessed as Parkin Ser65 phosphorylation at 50 uM after 24 hrs in absence of CCCP by immunoblotting analysis | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 6. | ALA4050844 | A | Stability in pH 7.4 trizma buffer assessed as cathepsin A (unknown origin)-mediated compound hydrolysis at 5.0 mg measured after 15 mins by 31P-NMR spectroscopic analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 7. | ALA4050846 | A | Prodrug activation in pH 7.4 trizma buffer assessed as cathepsin A (unknown origin)-mediated kinetin riboside monophosphate metabolite formation at 5.0 mg measured after 48 hrs by 31P-NMR spectroscopic analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 8. | ALA4050847 | A | Stability in pH 7.4 trizma buffer assessed as cathepsin A (unknown origin)-mediated compound hydrolysis by measuring parent compound remaining at 5.0 mg measured after 12 hrs by 31P-NMR spectroscopic analysis | Homo sapiens | 2 | single protein format | Scientific Literature |
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