| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3999063 | B | Inhibition of 5'-biotin-labeled c-Myc Pu18 G-quadruplex DNA (unknown origin) interaction with His-tagged NM23-H2 assessed as ratio of Kd for NM23-H2-DNA complex in presence of compound to Kd for NM2-H2-DNA complex in absence of compound at 20 uM preincubated with NM23-H2 for 1 hr followed by addition of DNA measured after overnight incubation by ELISA | Not specified | 13 | assay format | Scientific Literature | ||
| 2. | ALA3999066 | B | Stabilization of 5'-FAM/3'-TAMRA labeled c-Myc Pu18 G-quadruplex DNA (unknown origin) assessed as change in melting temperature at 1 uM after overnight incubation by FRET assay | Not specified | 4 | assay format | Scientific Literature | ||
| 3. | ALA3999067 | B | Inhibition of thiazole orange binding to c-Myc Pu18 G-quadruplex DNA (unknown origin) at 10 uM after 30 secs by fluorescence spectrophotometric method | Not specified | 8 | assay format | Scientific Literature | ||
| 4. | ALA3999068 | B | Inhibition of thiazole orange binding to c-Myc Pu27 G-quadruplex DNA (unknown origin) at 10 uM after 30 secs by fluorescence spectrophotometric method | Not specified | 8 | assay format | Scientific Literature | ||
| 5. | ALA3999074 | A | Cytotoxicity against human SiHa cells assessed as reduction in cell viability up to 2.2 uM after 48 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA3999075 | B | Inhibition of NM23-H2 binding to c-Myc promoter DNA in human SiHa cell nuclear extract after 4 days by ChIP analysis | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 7. | ALA3999078 | B | Inhibition of NM23-H2 binding to c-Myc G-quadruplex DNA in human SiHa cells assessed as downregulation of c-Myc mRNA level after 4 days by RT-PCR method | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 8. | ALA3999080 | F | Effect on NM23-H2 mRNA level in human SiHa cells up to 2.2 uM after 4 days by RT-PCR method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA3999081 | B | Inhibition of NM23-H2 binding to c-Myc G-quadruplex DNA in human SiHa cells assessed as downregulation of c-Myc protein expression at 0.5 times cytotoxic IC50 after 4 days by Western blot method | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 10. | ALA3999083 | F | Effect on NM23-H2 protein expression in human SiHa cells up to 2.2 uM after 4 days by Western blot method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA3999084 | B | Transrepression of c-Myc Pu43 G-quadruplex DNA (unknown origin) expressed in human SiHa cells after 48 hrs by luciferase reporter gene assay | Not specified | 2 | cell-based format | Scientific Literature | ||
| 12. | ALA3999088 | B | Transrepression of c-Myc Pu43 G-quadruplex DNA (unknown origin) expressed in human SiHa cells at 1.1 uM after 48 hrs by luciferase reporter gene assay relative to control | Not specified | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA3999089 | B | Transrepression of c-Myc Pu43 G-quadruplex DNA (unknown origin) expressed in human SiHa cells at 1.65 uM after 48 hrs by luciferase reporter gene assay relative to control | Not specified | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA3999090 | B | Transrepression of c-Myc Pu43 G-quadruplex DNA (unknown origin) expressed in human SiHa cells at 2.2 uM after 48 hrs by luciferase reporter gene assay relative to control | Not specified | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA3999092 | B | Transrepression of c-Myc MUT Pu43 DNA (unknown origin) expressed in human SiHa cells up to 2.2 uM after 48 hrs by luciferase reporter gene assay relative to control | Not specified | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA3999094 | B | Transrepression of c-Myc G-quadruplex DNA in human SiHa cells at 2.2 uM after 96 hrs by DAPI staining based immunofluoresence microscopic method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA3999095 | B | Induction of G-quadruplex formation in wild type c-Myc Pu43 DNA (unknown origin) in pH 7.4 Tris HCl at 25 uM after overnight incubation in absence of Kcl by CD spectroscopic analysis | Not specified | 2 | assay format | Scientific Literature | ||
| 18. | ALA3999097 | F | Growth inhibition of human SiHa cells after 40 hrs by real time cellular analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA3999098 | A | Growth inhibition of mouse primary mesangial cells at 0.25 to 1 times cytotoxic IC50 after 100 hrs by real time cellular analysis | Mus musculus | 2 | cell-based format | Scientific Literature | ||
| 20. | ALA3999099 | B | Inhibition of NM23-H2 binding to c-Myc G-quadruplex DNA in human SiHa cells assessed as effect on phosphorylated p53 protein expression by Western blot method | Homo sapiens | 2 | cell-based format | Scientific Literature |
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