| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4046665 | B | Inhibition of wild-type HCV genotype 1b NS5B RNA dependent RNA polymerase | Hepatitis C virus subtype 1b | 3 | ALA4043192 | assay format | Scientific Literature | |
| 2. | ALA4046666 | B | Inhibition of HCV genotype 1b NS5B RNA dependent RNA polymerase S282T mutant | Hepatitis C virus subtype 1b | 3 | ALA4043192 | assay format | Scientific Literature | |
| 3. | ALA4046667 | B | Selectivity ratio of IC50 for HCV genotype 1b NS5B RNA dependent RNA polymerase S282T mutant to IC50 for wild-type HCV genotype 1b NS5B RNA dependent RNA polymerase | Hepatitis C virus subtype 1b | 3 | ALA4043192 | assay format | Scientific Literature | |
| 4. | ALA4046668 | B | Inhibition of HCV genotype 1a NS5B RNA dependent RNA polymerase assessed as reduction in [33P]-labeled nucleotide incorporation in to RNA template after 2 hrs by liquid scintillation counting method | Hepatitis C virus subtype 1a | 1 | ALA4043192 | assay format | Scientific Literature | |
| 5. | ALA4046669 | B | Inhibition of HCV genotype 2a NS5B RNA dependent RNA polymerase assessed as reduction in [33P]-labeled nucleotide incorporation in to RNA template after 2 hrs by liquid scintillation counting method | Hepatitis C virus subtype 2a | 1 | ALA4043192 | assay format | Scientific Literature | |
| 6. | ALA4046671 | B | Inhibition of HCV genotype 3a NS5B RNA dependent RNA polymerase assessed as reduction in [33P]-labeled nucleotide incorporation in to RNA template after 2 hrs by liquid scintillation counting method | Hepatitis C virus subtype 3a | 1 | ALA4043192 | assay format | Scientific Literature | |
| 7. | ALA4046672 | B | Inhibition of HCV genotype 4a NS5B RNA dependent RNA polymerase assessed as reduction in [33P]-labeled nucleotide incorporation in to RNA template after 2 hrs by liquid scintillation counting method | Hepatitis C virus subtype 4a | 1 | ALA4043192 | assay format | Scientific Literature | |
| 8. | ALA4046673 | B | Inhibition of HCV genotype 5a NS5B RNA dependent RNA polymerase assessed as reduction in [33P]-labeled nucleotide incorporation in to RNA template after 2 hrs by liquid scintillation counting method | Hepatitis C virus subtype 5a | 1 | ALA4043192 | assay format | Scientific Literature | |
| 9. | ALA4046674 | B | Inhibition of HCV genotype 6a NS5B RNA dependent RNA polymerase assessed as reduction in [33P]-labeled nucleotide incorporation in to RNA template after 2 hrs by liquid scintillation counting method | Hepatitis C virus subtype 6a | 1 | ALA4043192 | assay format | Scientific Literature | |
| 10. | ALA4046675 | B | Inhibition of human DNA polymerase alpha | Homo sapiens | 1 | ALA4043192 | single protein format | Scientific Literature | |
| 11. | ALA4046676 | B | Inhibition of human DNA polymerase beta | Homo sapiens | 1 | ALA4043192 | single protein format | Scientific Literature | |
| 12. | ALA4046677 | B | Inhibition of human DNA polymerase gamma | Homo sapiens | 1 | ALA4043192 | assay format | Scientific Literature | |
| 13. | ALA4046678 | B | Inhibition of human RNA polymerase 2 | Homo sapiens | 1 | ALA4043192 | assay format | Scientific Literature | |
| 14. | ALA4046679 | B | Inhibition of human mitochondrial RNA polymerase | Homo sapiens | 1 | ALA4043192 | single protein format | Scientific Literature | |
| 15. | ALA4046694 | A | Half life in human hepatocytes | Homo sapiens | 1 | ALA4043192 | cell-based format | Scientific Literature | |
| 16. | ALA4394394 | A | Inhibition of human DNA polymerase-alpha assessed as reduction in [3H]dTTP incorporation in to activated calf thymus DNA substrate at 100 uM by scintillation counting method relative to control | Homo sapiens | 8 | ALA4393666 | single protein format | Scientific Literature | |
| 17. | ALA4394396 | A | Inhibition of human DNA polymerase-beta assessed as reduction in [3H]dTTP incorporation in to activated calf thymus DNA substrate at 100 uM by scintillation counting method relative to control | Homo sapiens | 8 | ALA4393666 | single protein format | Scientific Literature | |
| 18. | ALA4394397 | A | Inhibition of human DNA polymerase-gamma assessed as reduction in [3H]dTTP incorporation in to activated calf thymus DNA substrate at 100 uM by scintillation counting method relative to control | Homo sapiens | 8 | ALA4393666 | single protein format | Scientific Literature | |
| 19. | ALA4394398 | A | Inhibition of RNA polymerase 2 in human HeLa cell nuclear extract assessed as reduction in RNA transcription by PAGE analysis | Homo sapiens | 8 | ALA4393666 | cell-based format | Scientific Literature | |
| 20. | ALA4394399 | A | Inhibition of human mitochondrial DNA-dependent RNA polymerase activity at 100 uM using 33P-RNA/DNA primer/template by phosphor-imaging analysis | Homo sapiens | 4 | ALA4393666 | single protein format | Scientific Literature |
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