| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4055912 | A | Inhibition of human recombinant MMP-8 catalytic domain (99 to 269 residues) expressed in Escherichia coli using fluorogenic Mca-KPLGL-Dpa-AR-NH2 as substrate by fluorescence spectrophotometric analysis | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 2. | ALA4055913 | B | Inhibition of human recombinant MMP-14 catalytic domain (1 to 501 residues) using fluorogenic MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate at 10 uM by fluorescence spectrophotometric analysis relative to control | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 3. | ALA4055914 | B | Inhibition of human recombinant MMP-13 catalytic domain (104 to 274 residues) expressed in Escherichia coli using fluorogenic Mca-KPLGL-Dpa-AR-NH2 as substrate by fluorescence spectrophotometric analysis | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 4. | ALA4055916 | A | Inhibition of human recombinant MMP-8 catalytic domain (99 to 269 residues) expressed in Escherichia coli using fluorogenic Mca-KPLGL-Dpa-AR-NH2 as substrate at 10 uM by fluorescence spectrophotometric analysis relative to control | Homo sapiens | 8 | assay format | Scientific Literature | ||
| 5. | ALA4055917 | B | Inhibition of human recombinant MMP-13 catalytic domain (104 to 274 residues) expressed in Escherichia coli using fluorogenic Mca-KPLGL-Dpa-AR-NH2 as substrate at 10 uM by fluorescence spectrophotometric analysis relative to control | Homo sapiens | 8 | assay format | Scientific Literature | ||
| 6. | ALA4055918 | B | Inhibition of human recombinant MMP-1 catalytic domain (100 to 268 residues) expressed in Escherichia coli using fluorogenic Mca-KPLGL-Dpa-AR-NH2 as substrate at 10 uM by fluorescence spectrophotometric analysis | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 7. | ALA4055919 | B | Inhibition of human recombinant full length active MMP-2 expressed in mouse cells using fluorogenic MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate at 10 uM by fluorescence spectrophotometric analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 8. | ALA4055920 | B | Inhibition of human recombinant MMP-3 catalytic domain expressed in Escherichia coli using fluorogenic MOCAc-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2 as substrate at 10 uM by fluorescence spectrophotometric analysis | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 9. | ALA4055921 | B | Inhibition of human recombinant active MMP-7 expressed in Escherichia coli using fluorogenic MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate at 10 uM by fluorescence spectrophotometric analysis | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 10. | ALA4055922 | B | Inhibition of human recombinant MMP-9 catalytic domain (107 to 449 residues) expressed in Escherichia coli using fluorogenic MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate at 10 uM by fluorescence spectrophotometric analysis | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 11. | ALA4055923 | B | Inhibition of human recombinant MMP-14 catalytic domain (89 to 265 residues) expressed in Escherichia coli using fluorogenic MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate at 10 uM by fluorescence spectrophotometric analysis | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 12. | ALA4055924 | U | Selectivity ratio of Ki for human recombinant MMP-13 catalytic domain (104 to 274 residues) to Ki for human recombinant MMP-8 catalytic domain (99 to 269 residues) | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 13. | ALA4055925 | A | Plasma concentration in CD-1 mouse at 1 mg/kg, iv administered as single dose after 2 mins by UPLC analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA4055926 | A | Plasma concentration in CD-1 mouse at 1 mg/kg, iv administered as single dose after 24 hrs by UPLC analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA4055927 | A | AUC (0 to infinity) in CD-1 mouse at 1 mg/kg, iv administered as single dose by UPLC analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA4055928 | A | Clearance in CD-1 mouse at 1 mg/kg, iv administered as single dose by UPLC analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA4055929 | A | Volume of distribution in CD-1 mouse at 1 mg/kg, iv administered as single dose by UPLC analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA4055930 | A | Elimination half life in CD-1 mouse at 1 mg/kg, iv administered as single dose by UPLC analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA4055931 | A | Cmax in CD-1 mouse at 10 mg/kg, po after 6 hrs by UPLC analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA4055932 | A | Cmax in CD-1 mouse at 10 mg/kg, po after 48 hrs by UPLC analysis | Mus musculus | 1 | organism-based format | Scientific Literature |
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