| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4002315 | B | Displacement of ovine [125-I]-CRF from human CRF1 receptor expressed in CHO cell membranes after 1.5 hrs by liquid scintillation counting method | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
| 2. | ALA4002316 | A | Clearance in human hepatic microsomes at 1 umol/L after 20 mins in presence of NADPH generating system by UV detector-based HPLC method | Homo sapiens | 16 | assay format | Scientific Literature | ||
| 3. | ALA4002320 | F | Ex vivo displacement of ovine [125-I]-CRF from CRF1 receptor in po dosed Wistar rat pituitary after 2 hrs by gamma scintillation counting method | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 4. | ALA4002321 | F | Antagonist activity at human CRF1 receptor expressed in CHO cells assessed as inhibition of human CRF-stimulated cAMP accumulation | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA4002322 | B | Binding affinity to human CRF2alpha receptor at 10 uM | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 6. | ALA4002323 | B | Binding affinity to human CRF2beta receptor at 10 uM | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 7. | ALA4002324 | A | AUC in rat at 1 mg/kg, po | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 8. | ALA4002325 | A | Oral bioavailability in rat at 1 mg/kg | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 9. | ALA4002326 | B | Displacement of ovine [125-I]-CRF from human CRF1 receptor expressed in CHO cell membranes preincubated for 1 hr followed by [125I]-CRF addition measured after 1 hr by liquid scintillation counting method | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 10. | ALA4002327 | B | Displacement of ovine [125-I]-CRF from human CRF1 receptor expressed in CHO cell membranes preincubated for 1 hr followed by compound washout for 2 hrs and subsequent addition of [125I]-CRF measured after 1 hr by liquid scintillation counting method | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 11. | ALA4002328 | B | Ratio of IC50 for displacement of ovine [125-I]-CRF from human CRF1 receptor expressed in CHO cell membranes with compound washout to IC50 for displacement of ovine [125-I]-CRF from human CRF1 receptor expressed in CHO cell membranes without compound washout | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 12. | ALA4002329 | F | Ex vivo displacement of ovine [125-I]-CRF from CRF1 receptor in po dosed Wistar rat olfactory bulb after 2 hrs by gamma scintillation counting method | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA4002330 | F | Ex vivo displacement of ovine [125-I]-CRF from CRF1 receptor in po dosed Wistar rat frontal cortex after 2 hrs by gamma scintillation counting method | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA4002331 | F | Inhibition of forced swim stress-induced ACTH secretion in po dosed Wistar rat administered 2 hrs followed by forced swim stress test for 90 secs measured after 5 mins by radioimmunoassay | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA4002332 | F | Inhibition of CRF-induced anxious/depressive behavior in rat at 2.5 to 10 mg/kg, po | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA4002333 | F | Inhibition of stress-induced anxious/depressive behavior in rat at 2.5 to 10 mg/kg, po | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA4002334 | T | Toxicity in rat after 13 weeks | Rattus norvegicus | 1 | assay format | Scientific Literature | ||
| 18. | ALA4002335 | T | Toxicity in dog after 13 weeks | Canis lupus familiaris | 1 | assay format | Scientific Literature | ||
| 19. | ALA4002336 | A | Drug metabolism in human hepatic microsomes assessed as 3-(4-chloro-2-(2,4-dichloro-6-methylphenoxy)-1-methyl-1H-benzo[d]imidazol-7-yl)pentan-2-ol formation at 1 umol/L after 20 mins in presence of NADPH generating system by UV detector-based HPLC method | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 20. | ALA4002337 | A | Drug metabolism in human hepatic microsomes assessed as 3-(4-chloro-2-(2,4-dichloro-6-methylphenoxy)-1-methyl-1H-benzo[d]imidazol-7-yl)pentan-2-one formation at 1 umol/L after 20 mins in presence of NADPH generating system by UV detector-based HPLC method | Homo sapiens | 1 | assay format | Scientific Literature |
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