| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4017020 | B | Inhibition of HDAC1/2/3/6 in human CAL27 cells assessed as potentiation of cisplatin-induced cytotoxicity by measuring fold reduction in cisplatin IC50 at 500 nM preincubated for 48 hrs followed by cisplatin addition measured after 72 hrs by MTT assay relative to control | Homo sapiens | 1 | ALA4014348 | cell-based format | Scientific Literature | |
| 2. | ALA4017021 | B | Inhibition of HDAC1/2/3/6 in human A2780 cells using Boc-Lys(epsilon-Ac)-AMC as substrate preincubated for 18 hrs followed by substrate addition measured after 3 hrs by fluorescence assay | Homo sapiens | 17 | ALA4014348 | cell-based format | Scientific Literature | |
| 3. | ALA4017022 | B | Inhibition of HDAC1/2/3/6 in human A2780cisR cells using Boc-Lys(epsilon-Ac)-AMC as substrate preincubated for 18 hrs followed by substrate addition measured after 3 hrs by fluorescence assay | Homo sapiens | 17 | ALA4014348 | cell-based format | Scientific Literature | |
| 4. | ALA4017023 | B | Inhibition of HDAC1/2/3/6 in human Cal27 cells using Boc-Lys(epsilon-Ac)-AMC as substrate preincubated for 18 hrs followed by substrate addition measured after 3 hrs by fluorescence assay | Homo sapiens | 17 | ALA4014348 | cell-based format | Scientific Literature | |
| 5. | ALA4017024 | F | Cytotoxicity against human A2780cisR cells assessed as cell survival after 72 hrs by MTT assay | Homo sapiens | 17 | ALA4014348 | cell-based format | Scientific Literature | |
| 6. | ALA4017025 | F | Cytotoxicity against human A2780 cells assessed as cell survival after 72 hrs by MTT assay | Homo sapiens | 17 | ALA4014348 | cell-based format | Scientific Literature | |
| 7. | ALA4017026 | F | Cytotoxicity against human CAL27 cells assessed as cell survival after 72 hrs by MTT assay | Homo sapiens | 17 | ALA4014348 | cell-based format | Scientific Literature | |
| 8. | ALA4017027 | B | Inhibition of C-terminal FLAG/His-tagged recombinant human HDAC1 expressed in baculovirus infected Sf9 insect cells using Z-(Ac)Lys-AMC as substrate measured after 90 mins by fluorescence assay | Homo sapiens | 5 | ALA4014348 | cell-based format | Scientific Literature | |
| 9. | ALA4017028 | B | Inhibition of N-terminal GST-tagged recombinant human HDAC6 expressed in baculovirus infected Sf9 insect cells using Z-(Ac)Lys-AMC as substrate measured after 90 mins by fluorescence assay | Homo sapiens | 5 | ALA4014348 | cell-based format | Scientific Literature | |
| 10. | ALA4017029 | B | Inhibition of full length human recombinant C-terminal His-tagged HDAC3/NcoR2 expressed in baculovirus infected Sf9 insect cells using Boc-Lys(epsilon-Ac)-AMC as substrate measured after 90 mins by fluorescence assay | Homo sapiens | 5 | ALA4014348 | cell-based format | Scientific Literature | |
| 11. | ALA4017030 | B | Inhibition of full length human recombinant C-terminal FLAG-tagged HDAC2 expressed in baculovirus infected Sf9 insect cells using Boc-Lys(epsilon-Ac)-AMC as substrate measured after 90 mins by fluorescence assay | Homo sapiens | 5 | ALA4014348 | cell-based format | Scientific Literature | |
| 12. | ALA4017031 | B | Inhibition of human recombinant HDAC8 expressed in Escherichia coli using Z-L-Lys(epsilon-trifluoroacetyl)-AMC as substrate measured after 90 mins by fluorescence assay | Homo sapiens | 5 | ALA4014348 | assay format | Scientific Literature | |
| 13. | ALA4017032 | A | Apparent permeability in human Caco2 cells | Homo sapiens | 3 | ALA4014348 | cell-based format | Scientific Literature | |
| 14. | ALA4017033 | A | Apparent permeability in MDCK cells | Canis lupus familiaris | 3 | ALA4014348 | cell-based format | Scientific Literature | |
| 15. | ALA4017034 | B | Inhibition of human ERG | Homo sapiens | 3 | ALA4014348 | single protein format | Scientific Literature | |
| 16. | ALA4017035 | B | Inhibition of HDAC1/2/3/6 in human CAL27 cells assessed as potentiation of cisplatin-induced cytotoxicity by measuring fold reduction in cisplatin IC50 at 250 nM preincubated for 48 hrs followed by cisplatin addition measured after 72 hrs by MTT assay relative to control | Homo sapiens | 1 | ALA4014348 | cell-based format | Scientific Literature | |
| 17. | ALA4017036 | B | Inhibition of HDAC1/2/3/6 in human Cal27CisR cells assessed as potentiation of cisplatin-induced cytotoxicity by measuring fold reduction in cisplatin IC50 at 250 nM preincubated for 48 hrs followed by cisplatin addition measured after 72 hrs by MTT assay relative to control | Homo sapiens | 1 | ALA4014348 | cell-based format | Scientific Literature | |
| 18. | ALA4017038 | B | Inhibition of HDAC1/2/3/6 in human Cal27CisR cells assessed as potentiation of cisplatin-induced cytotoxicity by measuring fold reduction in cisplatin IC50 at 500 nM preincubated for 48 hrs followed by cisplatin addition measured after 72 hrs by MTT assay relative to control | Homo sapiens | 1 | ALA4014348 | cell-based format | Scientific Literature | |
| 19. | ALA4017041 | B | Inhibition of HDAC1/2/3/6 in human Cal27 cells assessed as potentiation of cisplatin-induced apoptosis at 250 to 500 nM preincubated for 48 hrs followed by cisplatin addition by flow cytomertry assay | Homo sapiens | 1 | ALA4014348 | cell-based format | Scientific Literature | |
| 20. | ALA4017042 | B | Inhibition of HDAC1/2/3/6 in human Cal27CisR cells assessed as potentiation of cisplatin-induced apoptosis at 250 to 500 nM preincubated for 48 hrs followed by cisplatin addition by flow cytomertry assay | Homo sapiens | 1 | ALA4014348 | cell-based format | Scientific Literature |
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