| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4049137 | B | Inhibition of human PDE2A1 using 3',5'-[3H]cGMP as substrate after 30 mins by scintillation proximity assay | Homo sapiens | 41 | ALA4043302 | single protein format | Scientific Literature | |
| 2. | ALA4049138 | A | Intrinsic clearance in human hepatocytes assessed per million cells at 1 uM after 0.5 to 4 hrs by HPLC-HRMS method | Homo sapiens | 25 | ALA4043302 | cell-based format | Scientific Literature | |
| 3. | ALA4049139 | A | Apparent permeability across RRCK cells after 1.5 hrs | Canis lupus familiaris | 37 | ALA4043302 | cell-based format | Scientific Literature | |
| 4. | ALA4049171 | A | Drug metabolism in human liver microsomes assessed as 2-(3,4-Dimethoxybenzyl)-5-methyl-7-((2S,3S)-2,4,6-trihydroxy-6-phenylhexan-3-yl)imidazo[5,1-f ][1,2,4]triazin-4(3H)-one formation at 20 uM after 1 hr by UHPLC-UV-HRMS method | Homo sapiens | 1 | ALA4043302 | assay format | Scientific Literature | |
| 5. | ALA4049172 | A | Drug metabolism in human liver microsomes assessed as 7-((2S,3S)-2,6-Dihydroxy-6-phenylhexan-3-yl)-2-(3-hydroxy-4-methoxybenzyl)-5-methylimidazo[5,1-f ][1,2,4]triazin-4(3H)-one formation at 20 uM after 1 hr by UHPLC-UV-HRMS method | Homo sapiens | 1 | ALA4043302 | assay format | Scientific Literature | |
| 6. | ALA4049173 | A | Drug metabolism in human liver microsomes assessed as 7-((2S,3R)-2,6-Dihydroxy-6-phenylhexan-3-yl)-2-(3,4-dimethoxybenzyl)-5-methylimidazo[5,1-f][1,2,4]triazin-4(3H)-one diastereomer 1 formation at 20 uM after 1 hr by UHPLC-UV-HRMS method | Homo sapiens | 1 | ALA4043302 | assay format | Scientific Literature | |
| 7. | ALA4049174 | A | Drug metabolism in human liver microsomes assessed as 7-((2S,3R)-2,6-Dihydroxy-6-phenylhexan-3-yl)-2-(3,4-dimethoxybenzyl)-5-methylimidazo[5,1-f][1,2,4]triazin-4(3H)-one diastereomer 2 formation at 20 uM after 1 hr by UHPLC-UV-HRMS method | Homo sapiens | 1 | ALA4043302 | assay format | Scientific Literature | |
| 8. | ALA4049175 | A | Drug metabolism in human liver microsomes assessed as 2-(3,4-Dimethoxybenzyl)-7-((2S,3S)-2-hydroxy-6-oxo-6-phenylhexan-3-yl)-5-methylimidazo[5,1-f ][1,2,4]triazin-4(3H)-one formation at 20 uM after 1 hr by UHPLC-UV-HRMS method | Homo sapiens | 1 | ALA4043302 | assay format | Scientific Literature |
The page will load shortly, Thanks for your patience!