| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3998965 | A | Drug uptake in mouse plasma at 100 mg/kg, po via gavage at 0.5 to 4 hrs post dose by LC-MS/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 2. | ALA3998968 | F | Growth inhibition of aromatase inhibitor resistant human MCF7:5C cells assessed as DNA content after 6 days by Hoechst 33258 staining based fluorescence assay | Homo sapiens | 18 | cell-based format | Scientific Literature | ||
| 3. | ALA3998969 | F | Growth inhibition of tamoxifen-sensitive human MCF7:WS8 cells assessed as DNA content after 4 to 5 days by Hoechst 33258 staining based fluorescence assay | Homo sapiens | 18 | cell-based format | Scientific Literature | ||
| 4. | ALA3998973 | B | Induction of ERalpha degradation in tamoxifen-sensitive human MCF7:WS8 cells after 24 hrs by CellTag 700 staining based In-cell western assay | Homo sapiens | 9 | assay format | Scientific Literature | ||
| 5. | ALA3998974 | B | Antagonist activity at ERalpha in tamoxifen-sensitive human MCF7:WS8 cells assessed as inhibition of estradiol-induced response after 18 hrs by luciferase reporter gene assay | Homo sapiens | 7 | assay format | Scientific Literature | ||
| 6. | ALA3998975 | F | Growth inhibition of tamoxifen-sensitive human MCF7:WS8 spheroids assessed as cell growth at 100 nM treatment repeated every 2 to 3 days for 14 days by CellTiter-Glo assay relative to control | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 7. | ALA3998977 | B | Displacement of [3H]estradiol from full length recombinant human ESR1 expressed in insect cells by radiometric assay | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 8. | ALA3998979 | B | Displacement of [3H]estradiol from full length recombinant human ESR1 expressed in insect cells by radiometric assay relative to estradiol | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 9. | ALA3998983 | F | Antitumor activity against human MCF7:TAM1 cells xenografted in athymic nude mouse assessed as tumor regression at 100 mg/kg, po administered daily via gavage for 23 days relative to control | Homo sapiens | 4 | organism-based format | Scientific Literature |
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