# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4051302 | B | Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay | Homo sapiens | 32 | cell-based format | Scientific Literature | ||
2. | ALA4051303 | B | Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay relative to control | Homo sapiens | 32 | cell-based format | Scientific Literature | ||
3. | ALA4051304 | F | Agonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assay | Mus musculus | 30 | cell-based format | Scientific Literature | ||
4. | ALA4051305 | F | Agonist activity at mouse GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins by FLUO-4-AM dye-based FLIPR assay relative to control | Mus musculus | 30 | cell-based format | Scientific Literature | ||
5. | ALA4051306 | P | Octanol-buffer partition coefficient, log D of the compound at pH 7.4 after 30 mins by LC-UV based shake-flask method | 19 | small-molecule physicochemical format | Scientific Literature | |||
6. | ALA4051315 | A | Protein binding in mouse plasma assessed as unbound fraction after 24 hrs by equilibrium dialysis | Mus musculus | 5 | cell-free format | Scientific Literature | ||
7. | ALA4051317 | A | Clearance in mouse at 1 mg/kg, iv after 24 hrs | Mus musculus | 1 | organism-based format | Scientific Literature | ||
8. | ALA4051319 | A | Volume of distribution at steady state in mouse at 1 mg/kg, iv after 24 hrs | Mus musculus | 1 | organism-based format | Scientific Literature | ||
9. | ALA4051320 | A | Cmax in mouse at 5 mg/kg administered through oral gavage after 24 hrs | Mus musculus | 5 | organism-based format | Scientific Literature | ||
10. | ALA4051321 | A | Oral bioavailability in mouse at 5 mg/kg after 24 hrs | Mus musculus | 5 | organism-based format | Scientific Literature | ||
11. | ALA4051322 | A | Ratio of drug level in mouse brain to blood at 5 mg/kg administered through oral gavage after 2 hrs | Mus musculus | 5 | organism-based format | Scientific Literature | ||
12. | ALA4051323 | A | Ratio of unbound drug level in mouse brain to blood at 5 mg/kg administered through oral gavage after 2 hrs | Mus musculus | 4 | organism-based format | Scientific Literature | ||
13. | ALA4051324 | A | Apparent permeability across apical to basolateral side in human Caco2 cells | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
14. | ALA4051325 | A | Efflux ratio of permeability in MDCK2-MDR1 cells at 10 uM | Canis lupus familiaris | 4 | cell-based format | Scientific Literature | ||
15. | ALA4051326 | F | Antidiabetic activity in C57BL/6J mouse assessed as reduction in glucose excursion at 100 mg/kg administered through oral gavage 30 mins prior to glucose challenge measured after 90 mins by OGTT relative to control | Mus musculus | 2 | organism-based format | Scientific Literature | ||
16. | ALA4051327 | F | Antidiabetic activity in wild-type mouse assessed as reduction in glucose excursion at 100 mg/kg administered through oral gavage 30 mins prior to glucose challenge measured after 90 mins by OGTT relative to control | Mus musculus | 2 | organism-based format | Scientific Literature | ||
17. | ALA4051328 | F | Antidiabetic activity in GPR120 knockout mouse assessed as reduction in glucose excursion at 100 mg/kg administered through oral gavage 30 mins prior to glucose challenge measured after 90 mins by OGTT | Mus musculus | 2 | organism-based format | Scientific Literature | ||
18. | ALA4051329 | B | Inhibition of Adenosine A2A receptor (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
19. | ALA4051331 | B | Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay | Mus musculus | 7 | cell-based format | Scientific Literature | ||
20. | ALA4051332 | B | Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay relative to control | Mus musculus | 7 | cell-based format | Scientific Literature |