#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA4019530	Binding	Inhibition of recombinant human N-terminal His-tagged KHK-C expressed in Escherichia coli BL21(DE3) using fructose as substrate incubated for 30 mins followed by ATP addition measured for 30 mins by pyruvate kinase-lactate dehydrogenase coupled enzyme assay	Homo sapiens	1	ALA4017511	assay format	Scientific Literature
2.	ALA4019533	Binding	Inhibition of recombinant rat N-terminal His-tagged KHK expressed in Escherichia coli BL21(DE3) using fructose as substrate incubated for 30 mins followed by ATP addition measured for 30 mins by pyruvate kinase-lactate dehydrogenase coupled enzyme assay	Rattus norvegicus	2	ALA4017511	assay format	Scientific Literature
3.	ALA4019534	ADME	Apparent clearance in human liver microsomes	Homo sapiens	5	ALA4017511	assay format	Scientific Literature
4.	ALA4019535	Physicochemical	Octanol/water partition coefficient, log D of the compound at pH 7.4 by shake-flask method		5	ALA4017511	small-molecule physicochemical format	Scientific Literature
5.	ALA4019536	ADME	Apparent permeability in RRCK cells by LC-MS/MS analysis	Canis lupus familiaris	2	ALA4017511	cell-based format	Scientific Literature
6.	ALA4019537	Physicochemical	Thermodynamic solubility of compound at pH 7.4		2	ALA4017511	small-molecule physicochemical format	Scientific Literature
7.	ALA4019538	ADME	Fraction unbound in human plasma at 10 uM measured at 2 to 24 hrs by equilibrium dialysis method	Homo sapiens	2	ALA4017511	cell-free format	Scientific Literature
8.	ALA4019539	ADME	Clearance in rat at 1 mg/kg, iv	Rattus norvegicus	1	ALA4017511	organism-based format	Scientific Literature
9.	ALA4019540	ADME	Volume of distribution in rat at 1 mg/kg, iv	Rattus norvegicus	1	ALA4017511	organism-based format	Scientific Literature
10.	ALA4019541	ADME	Half life in rat at 1 mg/kg, iv	Rattus norvegicus	1	ALA4017511	organism-based format	Scientific Literature
11.	ALA4019542	ADME	Oral bioavailability in rat at 5 mg/kg	Rattus norvegicus	1	ALA4017511	organism-based format	Scientific Literature
12.	ALA4019543	ADME	Cmax in rat at 5 mg/kg	Rattus norvegicus	1	ALA4017511	organism-based format	Scientific Literature
13.	ALA4019544	ADME	AUClast in rat at 5 mg/kg, po	Rattus norvegicus	1	ALA4017511	organism-based format	Scientific Literature
14.	ALA4019545	Unassigned	Time required for plasma concentration to reach above in vitro rat KHK IC50 in rat at 150 mg/kg, po	Rattus norvegicus	1	ALA4017511	organism-based format	Scientific Literature
15.	ALA4019546	Toxicity	Genotoxicity in Salmonella typhimurium by Ames test	Salmonella enterica subsp. enterica serovar Typhimurium	1	ALA4017511	assay format	Scientific Literature
16.	ALA4019547	ADME	Cytotoxicity against human HepG2 cells up to 300 uM after 72 hrs	Homo sapiens	1	ALA4017511	cell-based format	Scientific Literature
17.	ALA4019548	Functional	In vivo inhibition of KHK-C in po dosed Sprague-Dawley rat assessed as decrease in F1P levels in liver administered for 1 hr followed by bolus fructose administration measured 2 mins after iv infusion by LC/MS analysis	Rattus norvegicus	1	ALA4017511	organism-based format	Scientific Literature
18.	ALA4019549	Functional	In vivo inhibition of KHK-C in po dosed Sprague-Dawley rat assessed as decrease in F1P levels in kidney administered for 1 hr followed by bolus fructose administration measured 2 mins after iv infusion by LC/MS analysis	Rattus norvegicus	1	ALA4017511	organism-based format	Scientific Literature
19.	ALA4019550	Functional	In vivo inhibition of fructose metabolism in po dosed Sprague-Dawley rat assessed as increase in plasma fructose level administered for 1 hr followed by oral bolus fructose administration measured after 2 mins by LC/MS analysis	Rattus norvegicus	1	ALA4017511	organism-based format	Scientific Literature
20.	ALA4019551	Binding	Inhibition of human ERG	Homo sapiens	1	ALA4017511	single protein format	Scientific Literature