| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3993207 | B | Positive allosteric modulation of human glycine alpha3beta receptor expressed in HEK293T cells assessed as compound concentration required to induce up to 3-fold leftward shift in glycine-induced increase in chloride ion flux after 4 mins by Schild plot analysis | Homo sapiens | 35 | cell-based format | Scientific Literature | ||
| 2. | ALA3993208 | A | Intrinsic clearance in mouse liver microsomes up to 40 mins in presence of NADPH | Mus musculus | 23 | assay format | Scientific Literature | ||
| 3. | ALA3993209 | A | Passive apparent permeability in MDCK cells | Canis lupus familiaris | 15 | cell-based format | Scientific Literature | ||
| 4. | ALA3993210 | A | Efflux ratio of passive apparent permeability in MDCK cells harboring human MDR1 | Canis lupus familiaris | 15 | cell-based format | Scientific Literature | ||
| 5. | ALA3993230 | B | Positive allosteric modulation of human glycine alpha3 receptor expressed in HEK293T cells assessed as potentiation of glycine-induced increase in chloride ion flux after 4 mins by membrane potential blue dye based FLIPR assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 6. | ALA3993231 | B | Binding affinity to human glycine alpha3 receptor expressed in HEK293T cells by SPR assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 7. | ALA3993236 | A | Intrinsic clearance in human liver microsomes | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 8. | ALA4219619 | B | Positive allosteric modulation of human glycine alpha1 receptor expressed in HEK293T cells assessed as glycine-induced increase incurrent response after 18 to 24 hrs by membrane potential blue dye based FLIPR assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 9. | ALA4219620 | B | Positive allosteric modulation of human glycine alpha1beta receptor expressed in HEK293T cells assessed as glycine-induced increase in current response after 18 to 24 hrs by membrane potential blue dye based FLIPR assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 10. | ALA4219621 | B | Positive allosteric modulation of human glycine alpha3 receptor expressed in HEK293T cells assessed as glycine-induced increase in current response after 18 to 24 hrs by membrane potential blue dye based FLIPR assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 11. | ALA4219622 | B | Positive allosteric modulation of human glycine alpha3beta receptor expressed in HEK293T cells assessed as glycine-induced increase in current response after 18 to 24 hrs by membrane potential blue dye based FLIPR assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 12. | ALA4219623 | B | Positive allosteric modulation of human glycine alpha3beta receptor expressed in HEK293T cells assessed as potentiation of glycine-induced increase in current response after 18 to 24 hrs by membrane potential blue dye based FLIPR assay relative to glycine | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 13. | ALA4219624 | B | Agonist activity at alpha4beta2 nAChR (unknown origin) | Homo sapiens | 1 | protein complex format | Scientific Literature | ||
| 14. | ALA4219625 | B | Inhibition of alpha4beta2 nAChR (unknown origin) | Homo sapiens | 1 | protein complex format | Scientific Literature | ||
| 15. | ALA4219626 | B | Agonist activity at 5-HT3 receptor (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 16. | ALA4219627 | B | Inhibition of 5-HT3 receptor (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 17. | ALA4219628 | B | Positive allosteric modulation of C57BL/6 mouse GABAA receptor alpha1beta2gamma2 assessed as increase in GABA-induced current response at -60 mV holding potential by whole cell patch-clamp method relative to GABA | Mus musculus | 1 | protein complex format | Scientific Literature | ||
| 18. | ALA4219629 | B | Positive allosteric modulation of C57BL/6 mouse GABAA receptor alpha1beta3gamma2 assessed as increase in GABA-induced current response at -60 mV holding potential by whole cell patch-clamp method relative to GABA | Mus musculus | 1 | protein complex format | Scientific Literature | ||
| 19. | ALA4219630 | B | Inhibition of C57BL/6 mouse GABAA receptor alpha1beta3gamma2 | Mus musculus | 1 | protein complex format | Scientific Literature |
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