| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4358487 | Binding | Inhibition of full-length human recombinant BTK using FITC-Ahx-TSELKKVVALYDYMPMNAND-NH2 as substrate measured after 60 mins by caliper assay | Homo sapiens | 30 | ALA4354855 | single protein format | Scientific Literature | |
| 2. | ALA4358488 | Binding | Inhibition of BTK in vitamin D3 differentiated human THP1 cells assessed as inhibition of FCgammaR-induced IL8 production measured after 24 hrs by HTRF assay | Homo sapiens | 28 | ALA4354855 | assay format | Scientific Literature | |
| 3. | ALA4358489 | Binding | Inhibition of BTK in human B cells assessed as reduction in anti-IgM/IL4-stimulated CD69 expression on B cells preincubated for 60 mins followed by anti-IgM antibody/IL4 stimulation and measured after 16 hrs by flow cytometry | Homo sapiens | 28 | ALA4354855 | cell-based format | Scientific Literature | |
| 4. | ALA4358514 | Binding | Binding affinity to DNA-tagged recombinant BTK (unknown origin) measured after 1 hr by biotinylated-ligand affinity bead-based qPCR analysis | Homo sapiens | 6 | ALA4354855 | single protein format | Scientific Literature | |
| 5. | ALA4358515 | Binding | Binding affinity to DNA-tagged recombinant BMX (unknown origin) measured after 1 hr by biotinylated-ligand affinity bead-based qPCR analysis | Homo sapiens | 6 | ALA4354855 | single protein format | Scientific Literature | |
| 6. | ALA4358516 | ADME | Binding affinity to DNA-tagged recombinant TEC (unknown origin) measured after 1 hr by biotinylated-ligand affinity bead-based qPCR analysis | Homo sapiens | 6 | ALA4354855 | single protein format | Scientific Literature | |
| 7. | ALA4358517 | Binding | Binding affinity to DNA-tagged recombinant ITK (unknown origin) measured after 1 hr by biotinylated-ligand affinity bead-based qPCR analysis | Homo sapiens | 6 | ALA4354855 | single protein format | Scientific Literature | |
| 8. | ALA4358518 | ADME | Binding affinity to DNA-tagged recombinant EGFR (unknown origin) measured after 1 hr by biotinylated-ligand affinity bead-based qPCR analysis | Homo sapiens | 6 | ALA4354855 | single protein format | Scientific Literature | |
| 9. | ALA4358519 | Binding | Binding affinity to DNA-tagged recombinant ERBB2 (unknown origin) measured after 1 hr by biotinylated-ligand affinity bead-based qPCR analysis | Homo sapiens | 6 | ALA4354855 | single protein format | Scientific Literature | |
| 10. | ALA4358520 | Binding | Binding affinity to DNA-tagged recombinant ERBB4 (unknown origin) measured after 1 hr by biotinylated-ligand affinity bead-based qPCR analysis | Homo sapiens | 6 | ALA4354855 | single protein format | Scientific Literature | |
| 11. | ALA4358521 | Binding | Binding affinity to DNA-tagged recombinant JAK3 (unknown origin) measured after 1 hr by biotinylated-ligand affinity bead-based qPCR analysis | Homo sapiens | 6 | ALA4354855 | single protein format | Scientific Literature | |
| 12. | ALA4358522 | Binding | Selectivity ratio of Kd for DNA-tagged recombinant BMX (unknown origin) to Kd for DNA-tagged recombinant BTK (unknown origin) | Homo sapiens | 6 | ALA4354855 | assay format | Scientific Literature | |
| 13. | ALA4358523 | Binding | Selectivity ratio of Kd for DNA-tagged recombinant TEC (unknown origin) to Kd for DNA-tagged recombinant BTK (unknown origin) | Homo sapiens | 6 | ALA4354855 | assay format | Scientific Literature | |
| 14. | ALA4358524 | Binding | Selectivity ratio of Kd for DNA-tagged recombinant ITK (unknown origin) to Kd for DNA-tagged recombinant BTK (unknown origin) | Homo sapiens | 6 | ALA4354855 | assay format | Scientific Literature | |
| 15. | ALA4358525 | Binding | Selectivity ratio of Kd for DNA-tagged recombinant EGFR (unknown origin) to Kd for DNA-tagged recombinant BTK (unknown origin) | Homo sapiens | 6 | ALA4354855 | assay format | Scientific Literature | |
| 16. | ALA4358526 | Binding | Selectivity ratio of Kd for DNA-tagged recombinant ERBB2 (unknown origin) to Kd for DNA-tagged recombinant BTK (unknown origin) | Homo sapiens | 6 | ALA4354855 | assay format | Scientific Literature | |
| 17. | ALA4358527 | Binding | Selectivity ratio of Kd for DNA-tagged recombinant ERBB4 (unknown origin) to Kd for DNA-tagged recombinant BTK (unknown origin) | Homo sapiens | 6 | ALA4354855 | assay format | Scientific Literature | |
| 18. | ALA4358528 | Binding | Selectivity ratio of Kd for DNA-tagged recombinant JAK3 (unknown origin) to Kd for DNA-tagged recombinant BTK (unknown origin) | Homo sapiens | 6 | ALA4354855 | assay format | Scientific Literature | |
| 19. | ALA4358573 | Binding | Covalent binding affinity to BTK in human blood assessed as reduction in biotinylated-probe binding at 300 nM measured up to 100 mins by immunoassay relative to control | Homo sapiens | 6 | ALA4354855 | tissue-based format | Scientific Literature | |
| 20. | ALA4358574 | Binding | Inhibition of BTK in human basophils assessed as reduction in anti-IgE mouse IgG1 antibody Le2-stimulated CD63 expression on basophil preincubated for 30 mins in presence of IgE antibody B11 followed by anti-IgE mouse IgG1 antibody Le2 stimulation and measured after 15 mins by flow cytometry | Homo sapiens | 6 | ALA4354855 | assay format | Scientific Literature |
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