# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4044801 | P | Lipid/water partition coefficient, log P of the compound | 18 | small-molecule physicochemical format | Scientific Literature | |||
2. | ALA4044802 | A | Inhibition of COX-1 in rat peritoneal macrophages assessed as reduction in [125I]-6-Keto-PGF1alpha production using arachidonic acid as substrate pretreated for 30 mins followed by substrate addition measured after 30 mins | Rattus norvegicus | 19 | assay format | Scientific Literature | ||
3. | ALA4044803 | B | Inhibition of COX-2 in rat peritoneal macrophages assessed as reduction in PGE2 production using radiolabelled-arachidonic acid as substrate pretreated for 30 mins followed by substrate addition measured after 30 mins | Rattus norvegicus | 19 | assay format | Scientific Literature | ||
4. | ALA4044804 | U | Selectivity index, ratio of IC50 for COX1 in rat peritoneal macrophages to IC50 for COX2 in rat peritoneal macrophages | Rattus norvegicus | 19 | assay format | Scientific Literature | ||
5. | ALA4044805 | P | Dissociation constant, pKa of the compound | 18 | small-molecule physicochemical format | Scientific Literature | |||
6. | ALA4044806 | F | In-vivo inhibition of COX2 in rat at 20 mg/kg measured after 20 mins | Rattus norvegicus | 6 | organism-based format | Scientific Literature | ||
7. | ALA4044807 | F | In-vivo inhibition of COX2 in rat at 20 mg/kg measured after 40 mins | Rattus norvegicus | 6 | organism-based format | Scientific Literature | ||
8. | ALA4044808 | F | In-vivo inhibition of COX2 in rat at 20 mg/kg measured after 60 mins | Rattus norvegicus | 6 | organism-based format | Scientific Literature | ||
9. | ALA4044809 | F | In-vivo inhibition of COX2 in rat at 20 mg/kg measured after 90 mins | Rattus norvegicus | 6 | organism-based format | Scientific Literature | ||
10. | ALA4044810 | F | In-vivo inhibition of COX2 in rat at 20 mg/kg measured after 120 mins | Rattus norvegicus | 6 | organism-based format | Scientific Literature | ||
11. | ALA4044811 | F | Anti-inflammatory activity in rat assessed as reduction in PGE2 release at 20 mg/kg measured after 2 hrs | Rattus norvegicus | 5 | organism-based format | Scientific Literature |