| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4051356 | Binding | Inhibition of ERK2 (unknown origin) in the presence of 60 uM ATP | Homo sapiens | 26 | ALA4049432 | single protein format | Scientific Literature | |
| 2. | ALA4051357 | Binding | Inhibition of ERK2 (unknown origin) in the presence of 1 mM ATP | Homo sapiens | 27 | ALA4049432 | single protein format | Scientific Literature | |
| 3. | ALA4051358 | Binding | Inhibition of ERK2 in human A375 cells harboring BRAF V600E mutant assessed as decrease in phosphorylated ERK2 levels | Homo sapiens | 29 | ALA4049432 | cell-based format | Scientific Literature | |
| 4. | ALA4051359 | Binding | Inhibition of ERK2 in human A375 cells harboring BRAF V600E mutant assessed as decrease in phosphorylated RSK levels | Homo sapiens | 29 | ALA4049432 | cell-based format | Scientific Literature | |
| 5. | ALA4051360 | Physicochemical | Octanol-aqueous phosphate buffer distribution coefficient, log D of the compound at pH 7.4 | 26 | ALA4049432 | small-molecule physicochemical format | Scientific Literature | ||
| 6. | ALA4051361 | Physicochemical | Aqueous solubility of compound in pH 7.4 solution after 24 hrs | 26 | ALA4049432 | small-molecule physicochemical format | Scientific Literature | ||
| 7. | ALA4051363 | Binding | Inhibition of MEK1 (unknown origin) | Homo sapiens | 29 | ALA4049432 | single protein format | Scientific Literature | |
| 8. | ALA4051364 | ADME | Intrinsic clearance in human liver microsomes | Homo sapiens | 25 | ALA4049432 | assay format | Scientific Literature | |
| 9. | ALA4051365 | ADME | Intrinsic clearance in rat hepatocytes assessed as per million cells | Rattus norvegicus | 20 | ALA4049432 | cell-based format | Scientific Literature | |
| 10. | ALA4051368 | ADME | Intrinsic clearance in human hepatocytes assessed as per million cells | Homo sapiens | 6 | ALA4049432 | cell-based format | Scientific Literature | |
| 11. | ALA4051369 | Unassigned | Time at which free plasma concentration reach cellular pRSK IC50 level in nude mouse at 100 mg/kg, po via gavage | Mus musculus | 1 | ALA4049432 | organism-based format | Scientific Literature | |
| 12. | ALA4051370 | ADME | Fraction unbound in human plasma | Homo sapiens | 1 | ALA4049432 | cell-free format | Scientific Literature | |
| 13. | ALA4051371 | ADME | Fraction unbound in rat plasma | Rattus norvegicus | 1 | ALA4049432 | cell-free format | Scientific Literature | |
| 14. | ALA4051372 | ADME | Clearance in rat plasma | Rattus norvegicus | 1 | ALA4049432 | assay format | Scientific Literature | |
| 15. | ALA4051373 | ADME | Volume of distribution at steady state in rat plasma | Rattus norvegicus | 1 | ALA4049432 | assay format | Scientific Literature | |
| 16. | ALA4051374 | ADME | Oral bioavailability in rat | Rattus norvegicus | 1 | ALA4049432 | organism-based format | Scientific Literature | |
| 17. | ALA4051375 | ADME | Clearance in dog plasma | Canis lupus familiaris | 1 | ALA4049432 | assay format | Scientific Literature | |
| 18. | ALA4051376 | ADME | Volume of distribution at steady state in dog plasma | Canis lupus familiaris | 1 | ALA4049432 | assay format | Scientific Literature | |
| 19. | ALA4051377 | ADME | Oral bioavailability in dog | Canis lupus familiaris | 1 | ALA4049432 | organism-based format | Scientific Literature | |
| 20. | ALA4051378 | Functional | Decrease in phospho-p90RSK level in Foxn1 nude mouse xenografted with human Calu6 cells at 10 mg/kg to 100 mg/kg, po by Western blot analysis | Mus musculus | 1 | ALA4049432 | organism-based format | Scientific Literature |
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