# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3995154 | Binding | Inhibition of human placental cytosolic 17beta-HSD1 assessed as reduction in activation of [2,4,6,7-3H]-E1 substrate to E2 after 10 mins in presence of NADH by RP-HPLC method | Homo sapiens | 32 | ALA3994586 | assay format | Scientific Literature | |
2. | ALA3995155 | Binding | Inhibition of human placental microsomal 17beta-HSD2 using [2,4,6,7-3H]-E2 as substrate after 20 mins in presence of NAD+ by RP-HPLC method | Homo sapiens | 32 | ALA3994586 | assay format | Scientific Literature | |
3. | ALA3995156 | Binding | Selectivity ratio of IC50 for human placental microsomal 17beta-HSD2 to IC50 for human placental cytosolic 17beta-HSD1 | Homo sapiens | 32 | ALA3994586 | assay format | Scientific Literature | |
4. | ALA4051803 | Binding | Inhibition of human placental cytosolic 17beta-HSD1 using [3H]-E1/E1 substrate and NADH after 10 mins by HPLC based radio-detection method | Homo sapiens | 13 | ALA4049440 | assay format | Scientific Literature | |
5. | ALA4051804 | ADME | Inhibition of human placental cytosolic 17beta-HSD2 using [3H]-E2/E2 substrate and NAD+ after 20 mins by HPLC based radio-detection method | Homo sapiens | 13 | ALA4049440 | assay format | Scientific Literature | |
6. | ALA4051805 | Unassigned | Selectivity factor, ratio of IC50 for human placental cytosolic 17beta-HSD2 cells to IC50 for human placental cytosolic 17beta-HSD1 | Homo sapiens | 13 | ALA4049440 | assay format | Scientific Literature | |
7. | ALA4051808 | Binding | Inhibition of STS in human T47D cells at 1 uM preincubated for 1 hr followed by addition of [3H]-E1S/E1S as substrate measured after 24 hrs by HPLC based radio-detection method | Homo sapiens | 1 | ALA4049440 | cell-based format | Scientific Literature | |
8. | ALA4051809 | Binding | Inhibition of 17beta-HSD1 in human T47D cells preincubated for 1 hr followed by addition of [3H]-E1/E1 as substrate measured after 30 mins by HPLC based radio-detection method | Homo sapiens | 5 | ALA4049440 | cell-based format | Scientific Literature | |
9. | ALA4051811 | Binding | Irreversible inhibition of STS in human T47D cells at 1 uM preincubated for 2 hrs followed by compound washout and addition of [3H]-E1S/E1S as substrate measured after 24 hrs by HPLC based radio-detection method | Homo sapiens | 1 | ALA4049440 | cell-based format | Scientific Literature | |
10. | ALA4051813 | Functional | Antiproliferative activity against E1S/E1-stimulated human T47D cells assessed as cell viability at 50 to 200 nM measured after 7 days after MTT assay relative to control | Homo sapiens | 2 | ALA4049440 | cell-based format | Scientific Literature | |
11. | ALA4051815 | Binding | Inhibition of STS in human T47D cells assessed as [3H]-E1S level at 200 nM after 48 hrs by HPLC based radio-detection method (Rvb = 3.9%) | Homo sapiens | 2 | ALA4049440 | cell-based format | Scientific Literature | |
12. | ALA4051817 | Binding | Inhibition of 17beta-HSD1 in human T47D cells assessed as [3H]-E1 level at 200 nM after 48 hrs by HPLC based radio-detection method (Rvb = 0.9%) | Homo sapiens | 2 | ALA4049440 | cell-based format | Scientific Literature | |
13. | ALA4051819 | Binding | Inhibition of 17beta-HSD1 in human T47D cells assessed as [3H]-E2 level at 200 nM after 48 hrs by HPLC based radio-detection method (Rvb = 95.2%) | Homo sapiens | 2 | ALA4049440 | cell-based format | Scientific Literature | |
14. | ALA4051823 | Binding | Inhibition of human placental microsomal STS assessed as formation of E1 at 1 uM preincubated for 30 mins followed by addition of E1S as substrate measured after 20 mins by ELISA | Homo sapiens | 4 | ALA4049440 | assay format | Scientific Literature |