# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4047162 | Functional | Agonist activity at human CaSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by fluo-4AM dye based FLIPR assay | Homo sapiens | 20 | ALA4043225 | cell-based format | Scientific Literature | |
2. | ALA4047163 | Functional | Agonist activity at mouse CaSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by fluo-4AM dye based FLIPR assay | Mus musculus | 1 | ALA4043225 | cell-based format | Scientific Literature | |
3. | ALA4047164 | ADME | Apparent permeability of the compound in MDCK cells expressing human MRDR1 at 3 uM after 60 mins in presence of P-gp inhibitor GF120918A by LC-MS/MS analysis | Canis lupus familiaris | 19 | ALA4043225 | cell-based format | Scientific Literature | |
4. | ALA4047165 | ADME | Half-life in Sprague-Dawley rat cecal homogenates at 10 uM by LC-MS/MS analysis | Rattus norvegicus | 19 | ALA4043225 | tissue-based format | Scientific Literature | |
5. | ALA4047166 | ADME | Cmax in CD rat portal vein at 30 mg/kg, po administered via gavage | Rattus norvegicus | 4 | ALA4043225 | organism-based format | Scientific Literature | |
6. | ALA4047168 | ADME | Cmax in CD rat systemic circulation at 30 mg/kg, po administered via gavage | Rattus norvegicus | 4 | ALA4043225 | organism-based format | Scientific Literature | |
7. | ALA4047170 | ADME | Drug recovery in CD rat feces at 30 mg/kg, po administered via gavage measured by LC-MS/MS analysis | Rattus norvegicus | 4 | ALA4043225 | organism-based format | Scientific Literature | |
8. | ALA4047171 | ADME | AUC in CD rat portal vein at 10 mg/kg, po administered via gavage | Rattus norvegicus | 1 | ALA4043225 | organism-based format | Scientific Literature | |
9. | ALA4047172 | ADME | AUC in CD rat systemic circulation at 10 mg/kg, po administered via gavage | Rattus norvegicus | 1 | ALA4043225 | organism-based format | Scientific Literature | |
10. | ALA4047173 | ADME | Protein binding in CD rat plasma at 10 mg/kg, administered via gavage | Rattus norvegicus | 1 | ALA4043225 | organism-based format | Scientific Literature | |
11. | ALA4047174 | ADME | Unbound Cmax in CD rat portal vein at 10 mg/kg, po administered via gavage | Rattus norvegicus | 1 | ALA4043225 | organism-based format | Scientific Literature | |
12. | ALA4047175 | ADME | Unbound Cmax in CD rat systemic circulation at 10 mg/kg, po administered via gavage | Rattus norvegicus | 1 | ALA4043225 | organism-based format | Scientific Literature | |
13. | ALA4047176 | Functional | Agonist activity at rat CaSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by fluo-4AM dye based FLIPR assay | Rattus norvegicus | 1 | ALA4043225 | cell-based format | Scientific Literature | |
14. | ALA4047177 | Physicochemical | Aqueous solubility of the compound in FASSIF | 1 | ALA4043225 | small-molecule physicochemical format | Scientific Literature | ||
15. | ALA4047178 | Physicochemical | Aqueous solubility of the compound in FESSIF | 1 | ALA4043225 | small-molecule physicochemical format | Scientific Literature | ||
16. | ALA4047179 | Physicochemical | Aqueous solubility of the compound in SGF | 1 | ALA4043225 | small-molecule physicochemical format | Scientific Literature |