# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA701724 | Binding | In vitro inhibitory activity against HIV-1 integrase. | Human immunodeficiency virus 1 | 32 | ALA1128696 | single protein format | Scientific Literature | |
2. | ALA857173 | Binding | Inhibitory activity against HIV-1 Integrase (HIV-1-IN) | Human immunodeficiency virus 1 | 47 | ALA1135718 | single protein format | Scientific Literature | |
3. | ALA4414744 | Binding | Inhibition of 5-LO in human PMNL cells assessed as reduction in leukotriene formation at 1 uM preincubated for 5 mins followed by thapsigargin stimulation measured after 15 mins by RP-HPLC analysis relative to control | Homo sapiens | 5 | ALA4414547 | cell-based format | Scientific Literature | |
4. | ALA4414745 | Binding | Inhibition of 5-LO in human PMNL cells assessed as reduction in leukotriene formation preincubated for 5 mins followed by thapsigargin stimulation measured after 15 mins by RP-HPLC analysis | Homo sapiens | 5 | ALA4414547 | cell-based format | Scientific Literature | |
5. | ALA4414746 | Binding | Potency index, ratio of Zileuton IC50 to compound IC50 for inhibition of 5-LO in human PMNL cells assessed as reduction in leukotriene formation preincubated for 5 mins followed by thapsigargin stimulation measured after 15 mins by RP-HPLC analysis | Homo sapiens | 2 | ALA4414547 | cell-based format | Scientific Literature | |
6. | ALA4414747 | Binding | Potency index, ratio of CAPE IC50 to compound IC50 for inhibition of 5-LO in human PMNL cells assessed as reduction in leukotriene formation preincubated for 5 mins followed by thapsigargin stimulation measured after 15 mins by RP-HPLC analysis | Homo sapiens | 2 | ALA4414547 | cell-based format | Scientific Literature | |
7. | ALA4414748 | Functional | Antioxidant activity assessed as DPPH radical scavenging activity incubated for 30 mins under dark condition | 6 | ALA4414547 | assay format | Scientific Literature | ||
8. | ALA4414749 | Functional | Cytotoxicity against VHL-positive human RCC10 cells assessed as reduction in cell viability incubated for 4 days by XTT assay | Homo sapiens | 5 | ALA4414547 | cell-based format | Scientific Literature | |
9. | ALA4414750 | Functional | Induction of autophagy in VHL-deficient human RCC4 cells assessed as increase in conversion of LC3B1 to LC3B2 expression at 2.5 to 10 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4414547 | cell-based format | Scientific Literature | |
10. | ALA4414751 | Functional | Cytotoxicity against VHL-deficient human RCC4 cells assessed as reduction in cell viability incubated for 4 days by XTT assay | Homo sapiens | 5 | ALA4414547 | cell-based format | Scientific Literature | |
11. | ALA4414752 | Functional | Cytotoxicity against VHL-positive human RCC4/VHL cells assessed as reduction in cell viability incubated for 4 days by XTT assay | Homo sapiens | 5 | ALA4414547 | cell-based format | Scientific Literature | |
12. | ALA4414753 | Functional | Cytotoxicity against VHL-deficient human RCC10 cells assessed as reduction in cell viability incubated for 4 days by XTT assay | Homo sapiens | 5 | ALA4414547 | cell-based format | Scientific Literature | |
13. | ALA4414754 | Functional | Cytotoxicity against VHL-deficient human 786-0 cells assessed as reduction in cell viability incubated for 4 days by XTT assay | Homo sapiens | 5 | ALA4414547 | cell-based format | Scientific Literature | |
14. | ALA4414755 | Functional | Cytotoxicity against VHL-positive human 786-0 cells assessed as reduction in cell viability incubated for 4 days by XTT assay | Homo sapiens | 5 | ALA4414547 | cell-based format | Scientific Literature | |
15. | ALA4414756 | Functional | Induction of apoptosis in VHL-deficient human RCC4 cells assessed as cleavage of pro-caspase 3 after 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4414547 | cell-based format | Scientific Literature | |
16. | ALA4414757 | Functional | Induction of DNA damage in VHL-deficient human RCC4 cells assessed as induction of p53 expression at 2.5 to 10 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4414547 | cell-based format | Scientific Literature | |
17. | ALA4414759 | Functional | Induction of DNA damage in human RCC4/VHL cells assessed as induction of p53 expression at 2.5 to 10 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4414547 | cell-based format | Scientific Literature | |
18. | ALA4414762 | Functional | Induction of autophagy in human RCC4/VHL cells assessed as increase in conversion of LC3B1 to LC3B2 expression at 2.5 to 10 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4414547 | cell-based format | Scientific Literature | |
19. | ALA4414764 | Functional | Inhibition of autophagic flux in VHL-deficient human RCC4 cells assessed as increase in p62 expression at 2.5 to 10 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4414547 | cell-based format | Scientific Literature | |
20. | ALA4414765 | Functional | Inhibition of autophagic flux in human RCC4/VHL cells assessed as increase in p62 expression at 2.5 to 10 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4414547 | cell-based format | Scientific Literature |