| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4035969 | P | Aqueous solubility of the compound in phosphate buffer at pH 7.4 using crystalline sample | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 2. | ALA4035970 | B | Inhibition of PI3Kalpha (unknown origin) | Homo sapiens | 6 | single protein format | Scientific Literature | ||
| 3. | ALA4035971 | B | Inhibition of PI3Kbeta (unknown origin) | Homo sapiens | 6 | single protein format | Scientific Literature | ||
| 4. | ALA4035972 | B | Inhibition of PI3Kalpha mutant in human BT474 cells assessed as reduction in AKT phosphorylation at Thr308 | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 5. | ALA4035973 | B | Inhibition of PI3Kbeta in PTEN-deficient human MDA-MB-468 cells assessed as reduction in AKT phosphorylation at Ser473 | Homo sapiens | 8 | assay format | Scientific Literature | ||
| 6. | ALA4035974 | B | Selectivity ratio of IC50 for PI3Kbeta in PTEN-deficient human MDA-MB-468 cells to IC50 for PI3Kalpha mutant in human BT474 cells | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4035975 | P | Dissociation constant, pKa of the compound | 2 | small-molecule physicochemical format | Scientific Literature | |||
| 8. | ALA4035976 | P | Octanol-buffer partition coefficient, log D of the compound at pH 7.4 by shake-flask method | 2 | small-molecule physicochemical format | Scientific Literature | |||
| 9. | ALA4035978 | A | Apparent permeability of the compound across apical side to basolateral side in human Caco2 cells | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 10. | ALA4035979 | A | Clearance in Han Wistar rat at 4 umol/kg, iv or 10 umol/kg, po | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 11. | ALA4035980 | A | Volume of distribution in Han Wistar rat at 4 umol/kg, iv or 10 umol/kg, po | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 12. | ALA4035981 | A | Oral bioavailability in Han Wistar rat at 10 umol/kg | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 13. | ALA4035982 | A | Clearance in Beagle dog at 1 umol/kg, po | Canis lupus familiaris | 1 | assay format | Scientific Literature | ||
| 14. | ALA4035983 | A | Volume of distribution in Beagle dog at 1 umol/kg, po | Canis lupus familiaris | 1 | assay format | Scientific Literature | ||
| 15. | ALA4035984 | A | Oral bioavailability in Beagle dog at 1 umol/kg | Canis lupus familiaris | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA4035985 | A | AUC in mouse at 100 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA4035986 | A | Cmax in mouse at 100 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA4035987 | F | Anti-tumor activity against human MCF7 cells harboring PI3KCA E545K mutant xenografted in Swiss nu/nu mouse assessed as tumor growth inhibition at 50 mg/kg, po administered twice daily for 21 days measured post last dose relative to control | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA4035988 | F | Anti-tumor activity against human MCF7 cells harboring PI3KCA E545K mutant xenografted in Swiss nu/nu mouse assessed as tumor growth inhibition at 25 mg/kg, po administered twice daily for 21 days measured post last dose relative to control | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA4035989 | F | Anti-tumor activity against human MCF7 cells harboring PI3KCA E545K mutant xenografted in Swiss nu/nu mouse assessed as tumor growth inhibition at 10 mg/kg, po administered twice daily for 21 days measured post last dose relative to control | Homo sapiens | 1 | organism-based format | Scientific Literature |
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