# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4040390 | ADME | Stability in rat plasma assessed as parent compound remaining at 100 uM measured after 1 hr by HPLC analysis (Rvb = 49 to 86%) | Rattus norvegicus | 3 | ALA4038321 | cell-free format | Scientific Literature | |
2. | ALA4040391 | ADME | Stability in rat plasma assessed as parent compound remaining at 100 uM measured immediately by HPLC analysis (Rvb = 49 to 86%) | Rattus norvegicus | 3 | ALA4038321 | cell-free format | Scientific Literature | |
3. | ALA4040392 | ADME | Substrate activity at recombinant human cathepsin K expressed in Escherichia coli assessed as compound cleavage at 100 uM after 1 hr by HPLC analysis | Homo sapiens | 3 | ALA4038321 | assay format | Scientific Literature | |
4. | ALA4040393 | ADME | Substrate activity at recombinant rat cathepsin K expressed in Escherichia coli assessed as compound cleavage at 100 uM after 1 hr by HPLC analysis | Rattus norvegicus | 3 | ALA4038321 | assay format | Scientific Literature | |
5. | ALA4040394 | ADME | Substrate activity at recombinant human cathepsin K expressed in Escherichia coli assessed as compound cleavage at 100 uM after 3 hrs by HPLC analysis | Homo sapiens | 1 | ALA4038321 | assay format | Scientific Literature | |
6. | ALA4040395 | ADME | Stability in rat plasma assessed as parent compound remaining at 100 uM measured after 2 hrs by HPLC analysis (Rvb = 49 to 86%) | Rattus norvegicus | 3 | ALA4038321 | cell-free format | Scientific Literature | |
7. | ALA4040396 | ADME | Stability in rat plasma assessed as parent compound remaining at 100 uM measured after 4 hrs by HPLC analysis (Rvb = 49 to 86%) | Rattus norvegicus | 3 | ALA4038321 | cell-free format | Scientific Literature | |
8. | ALA4040397 | ADME | Stability in rat plasma assessed as parent compound remaining at 100 uM measured after 24 hrs by HPLC analysis (Rvb = 49 to 86%) | Rattus norvegicus | 3 | ALA4038321 | cell-free format | Scientific Literature | |
9. | ALA4040398 | ADME | Stability in rat serum assessed as parent compound remaining at 100 uM measured immediately by HPLC analysis (Rvb = 93 to 97%) | Rattus norvegicus | 3 | ALA4038321 | cell-free format | Scientific Literature | |
10. | ALA4040399 | ADME | Stability in rat serum assessed as parent compound remaining at 100 uM measured after 1 hr by HPLC analysis (Rvb = 93 to 97%) | Rattus norvegicus | 3 | ALA4038321 | cell-free format | Scientific Literature | |
11. | ALA4040400 | ADME | Stability in rat serum assessed as parent compound remaining at 100 uM measured after 2 hrs by HPLC analysis (Rvb = 93 to 97%) | Rattus norvegicus | 3 | ALA4038321 | cell-free format | Scientific Literature | |
12. | ALA4040401 | ADME | Stability in rat serum assessed as parent compound remaining at 100 uM measured after 4 hrs by HPLC analysis (Rvb = 93 to 97%) | Rattus norvegicus | 3 | ALA4038321 | cell-free format | Scientific Literature | |
13. | ALA4040402 | ADME | Stability in rat serum assessed as parent compound remaining at 100 uM measured after 24 hrs by HPLC analysis (Rvb = 93 to 97%) | Rattus norvegicus | 3 | ALA4038321 | cell-free format | Scientific Literature | |
14. | ALA4040403 | ADME | Substrate activity at recombinant human cathepsin K expressed in Escherichia coli assessed as compound cleavage at 100 uM after 2 hrs by HPLC analysis | Homo sapiens | 3 | ALA4038321 | assay format | Scientific Literature | |
15. | ALA4040404 | ADME | Substrate activity at recombinant rat cathepsin K expressed in Escherichia coli assessed as compound cleavage at 100 uM after 2 hrs by HPLC analysis | Rattus norvegicus | 3 | ALA4038321 | assay format | Scientific Literature | |
16. | ALA4040405 | ADME | Substrate activity at recombinant rat cathepsin K expressed in Escherichia coli assessed as compound cleavage at 100 uM after 20 hrs by HPLC analysis | Rattus norvegicus | 3 | ALA4038321 | assay format | Scientific Literature |