# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4002664 | B | Inhibition of recombinant human alpha GAL-A at 20 uM using 4-methylumbelliferyl alpha-D-galactopyranoside as substrate at pH 4.6 after 15 mins by fluorescence assay relative to control | Homo sapiens | 65 | single protein format | Scientific Literature | ||
2. | ALA4002665 | B | Inhibition of recombinant human alpha GAL-A using 4-methylumbelliferyl alpha-D-galactopyranoside as substrate at pH 4.6 after 15 mins by fluorescence assay | Homo sapiens | 7 | single protein format | Scientific Literature | ||
3. | ALA4002666 | B | Inhibition of recombinant human alpha GAL-A using 4-methylumbelliferyl alpha-D-galactopyranoside as substrate at pH 7 after 15 mins by fluorescence assay | Homo sapiens | 7 | single protein format | Scientific Literature | ||
4. | ALA4002667 | B | Stabilization of heat inactivated human recombinant alpha GAL-A assessed as restoration of enzyme activity at pH 4.6 preincubated for 10 mins followed by heat inactivation for 30 mins at 48 degC at pH 7 and subsequent addition of 4MU-alpha-galactopyranoside as substrate measured after 15 mins | Homo sapiens | 4 | single protein format | Scientific Literature | ||
5. | ALA4002669 | B | Chaperone activity assessed as enhancement of alpha GAL-A N215S mutant enzyme activity in Fabry patient derived lymphocytes up to 100 uM at pH 4.6 pretreated for 4 days followed by 4MU-alpha-galactopyranoside substrate addition in presence of N-acetylgalactosamine measured after 1 hr by fluorescence assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
6. | ALA4002688 | A | Cytotoxicity against human lymphocytes measured after 48 to 72 hrs by alamar blue assay | Homo sapiens | 7 | cell-based format | Scientific Literature |