# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4040853 | B | Displacement of [35S]TBPS from GABA-A receptor in Sprague-Dawley rat cerebral cortex cell membranes after 90 mins in presence of GABA by liquid scintillation counting | Rattus norvegicus | 21 | ALA4038335 | assay format | Scientific Literature | |
2. | ALA4040854 | B | Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-mediated increase in channel current under holding potential at -80 mV preincubated for 30 secs followed by GABA stimulation for 2 secs by automated patch clamp assay | Homo sapiens | 21 | ALA4038335 | cell-based format | Scientific Literature | |
3. | ALA4040855 | B | Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-mediated increase in channel current under holding potential at -80 mV at 0.01 to 10 uM preincubated for 30 secs followed by GABA stimulation for 2 secs by automated patch clamp assay relative to GABA | Homo sapiens | 21 | ALA4038335 | cell-based format | Scientific Literature | |
4. | ALA4040856 | B | Positive allosteric modulation of GABAA receptor alpha4beta3delta (unknown origin) expressed in CHO cells assessed as potentiation of GABA-mediated increase in channel current under holding potential at -80 mV preincubated for 30 secs followed by GABA stimulation for 2 secs by manual patch clamp assay | Homo sapiens | 21 | ALA4038335 | cell-based format | Scientific Literature | |
5. | ALA4040857 | B | Positive allosteric modulation of GABAA receptor alpha4beta3delta (unknown origin) expressed in CHO cells assessed as potentiation of GABA-mediated increase in channel current under holding potential at -80 mV at 0.01 to 10 uM preincubated for 30 secs followed by GABA stimulation for 2 secs by manual patch clamp assay relative to GABA | Homo sapiens | 21 | ALA4038335 | cell-based format | Scientific Literature | |
6. | ALA4040858 | P | Lipophilicity, logD of compound at 20 uM at pH 7.4 by HPLC/MS-MS analysis | 7 | ALA4038335 | small-molecule physicochemical format | Scientific Literature | ||
7. | ALA4040859 | P | Thermodynamic aqueous solubility of compound at 10 uM sonicated for 1 min followed by incubation for 1 hr by HPLC-MS/MS | 7 | ALA4038335 | small-molecule physicochemical format | Scientific Literature | ||
8. | ALA4040860 | A | Clearance in human hepatic microsomes at 10 uM preincubated for 5 mins followed by NADPH addition measured over 60 mins by HPLC-MS/MS analysis | Homo sapiens | 7 | ALA4038335 | assay format | Scientific Literature | |
9. | ALA4040861 | A | Clearance in rat hepatic microsomes at 10 uM preincubated for 5 mins followed by NADPH addition measured over 60 mins by HPLC-MS/MS analysis | Rattus norvegicus | 7 | ALA4038335 | assay format | Scientific Literature | |
10. | ALA4040862 | A | Clearance in mouse hepatic microsomes at 10 uM preincubated for 5 mins followed by NADPH addition measured over 60 mins by HPLC-MS/MS analysis | Mus musculus | 7 | ALA4038335 | assay format | Scientific Literature | |
11. | ALA4040863 | A | Clearance in Sprague-Dawley rat at 5 mg/kg, iv or 20 mg/kg, po measured up to 8 hrs post dose by LC/MS-MS analysis | Rattus norvegicus | 7 | ALA4038335 | organism-based format | Scientific Literature | |
12. | ALA4040864 | A | Clearance in CD1 mouse at 5 mg/kg, iv or 20 mg/kg, po measured up to 8 hrs post dose by LC/MS-MS analysis | Mus musculus | 7 | ALA4038335 | organism-based format | Scientific Literature | |
13. | ALA4040865 | A | Oral bioavailability in Sprague-Dawley rat at 20 mg/kg measured up to 8 hrs post dose by LC/MS-MS analysis | Rattus norvegicus | 7 | ALA4038335 | organism-based format | Scientific Literature | |
14. | ALA4040866 | A | Oral bioavailability in CD1 mouse at 20 mg/kg measured up to 8 hrs post dose by LC/MS-MS analysis | Mus musculus | 7 | ALA4038335 | organism-based format | Scientific Literature | |
15. | ALA4040867 | A | Ratio of drug level in Sprague-Dawley rat brain to plasma at 5 mg/kg, iv measured at 30 mins post dose by LC/MS-MS analysis | Rattus norvegicus | 7 | ALA4038335 | organism-based format | Scientific Literature | |
16. | ALA4040868 | A | Ratio of drug level in CD1 mouse brain to plasma at 5 mg/kg, iv measured at 30 mins post dose by LC/MS-MS analysis | Mus musculus | 7 | ALA4038335 | organism-based format | Scientific Literature |