| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4015894 | B | Inhibition of recombinant human His6-tagged DGAT1 expressed in Sf9 insect cell membranes assessed as inhibition of triglyceride formation using diolein/oleyl-CoA as substrate after 30 mins by LC/MS/MS analysis | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 2. | ALA4015895 | B | Inhibition of DGTA1 in mouse C2C12 cells assessed as inhibition of triglyceride formation after 2 hrs by LC/MS/MS analysis | Mus musculus | 4 | cell-based format | Scientific Literature | ||
| 3. | ALA4015896 | A | Permeability across apical to basolateral side in human Caco2 cells | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 4. | ALA4015897 | A | Permeability across basolateral to apical side in human Caco2 cells | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 5. | ALA4015898 | A | Efflux ratio of permeability across basolateral to apical side over apical to basolateral side in human Caco2 cells | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 6. | ALA4015900 | F | Antiobesity activity in fasted Beagle dog assessed as postprandial triglyceride AUC in plasma at 1 mg/kg administered via oral gavage prior to 30 mins of glucose-challenge measured after 4 hrs (Rvb = 35400 +/- 8863 mg/dL.min) | Canis lupus familiaris | 1 | organism-based format | Scientific Literature | ||
| 7. | ALA4015907 | T | Genotoxicity in histidine depleted Salmonella typhimurium TA98 assessed as increase in reverting mutations up to 1000 ug in presence of S9 metabolic activation by Ames test | Salmonella enterica subsp. enterica serovar Typhimurium | 1 | assay format | Scientific Literature | ||
| 8. | ALA4015908 | T | Genotoxicity in histidine depleted Salmonella typhimurium TA100 assessed as increase in reverting mutations up to 1000 ug in presence of S9 metabolic activation by Ames test | Salmonella enterica subsp. enterica serovar Typhimurium | 1 | assay format | Scientific Literature | ||
| 9. | ALA4015909 | T | Genotoxicity in histidine depleted Salmonella typhimurium TA98 assessed as increase in reverting mutations up to 1000 ug in absence of S9 metabolic activation by Ames test | Salmonella enterica subsp. enterica serovar Typhimurium | 1 | assay format | Scientific Literature | ||
| 10. | ALA4015910 | T | Genotoxicity in histidine depleted Salmonella typhimurium TA100 assessed as increase in reverting mutations up to 1000 ug in absence of S9 metabolic activation by Ames test | Salmonella enterica subsp. enterica serovar Typhimurium | 1 | assay format | Scientific Literature | ||
| 11. | ALA4015911 | A | Clearance in Sprague-Dawley rat at 1 mg/kg, iv by LC/MS/MS analysis | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
| 12. | ALA4015912 | A | Volume of distribution at steady state in Sprague-Dawley rat at 1 mg/kg, iv by LC/MS/MS analysis | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
| 13. | ALA4015913 | A | Half life in Sprague-Dawley rat at 1 mg/kg, iv by LC/MS/MS analysis | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
| 14. | ALA4015914 | A | AUC (0 to 8 hrs) in Sprague-Dawley rat at 1mg/kg, iv by LC/MS/MS analysis | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
| 15. | ALA4015919 | A | Cmax in Sprague-Dawley rat at 3 mg/kg, po by LC/MS/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 16. | ALA4015920 | A | Tmax in Sprague-Dawley rat 3 mg/kg, po by LC/MS/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 17. | ALA4015921 | A | AUC (0 to 8 hrs) in Sprague-Dawley rat at 3 mg/kg, po by LC/MS/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 18. | ALA4015922 | A | Oral bioavailability in Sprague-Dawley rat at 3 mg/kg by LC/MS/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 19. | ALA4015923 | F | Antiobesity activity in high fat-fed human assessed as suppression of postprandial plasma triglyceride level compound administered as single oral dose | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 20. | ALA4015924 | T | Toxicity in human assessed as diarrhea at 150 mg, po as single oral dose | Homo sapiens | 1 | organism-based format | Scientific Literature |
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